School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China.
J Org Chem. 2023 Apr 7;88(7):4352-4358. doi: 10.1021/acs.joc.2c02953. Epub 2023 Mar 17.
An unprecedented and challenging multicomponent reaction has been developed that allows for the direct transformation of acyl chlorides with alkynes into the corresponding saturated β-boryl ketones via Pd/Cu-catalyzed coupling and boration with ethyl acetate as the hydrogen sources. Various β-boryl ketones were synthesized in good to excellent yields with broad functional group tolerance. In addition, the introduction of boron groups into the products provides substantial opportunities for further conversions.
发展了一种前所未有的多组分反应，通过 Pd/Cu 催化偶联和以乙酸乙酯为氢源的硼化作用，可将酰氯与炔烃直接转化为相应的饱和β-硼酸酮。各种β-硼酸酮以良好至优异的产率合成，具有广泛的官能团容忍度。此外，产物中硼基团的引入为进一步转化提供了大量机会。
