Zhou Tian-Biao, Zhao Hui-Liu, Fang Si-Lian, Drummen Gregor P C
Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , China .
J Recept Signal Transduct Res. 2014 Dec;34(6):469-75. doi: 10.3109/10799893.2014.919594. Epub 2014 May 19.
The association of transforming growth factor-β1 (TGFβ1) is an important signaling pathway factor involving extracellular matrix regulation, and its gene polymorphisms with the risk of rheumatoid arthritis (RA) is currently still fiercely debated. Therefore, this meta-analysis was performed to determine if TGFβ1 T869C, G915C, and C509T gene polymorphisms correlate with the risk of developing RA. Association reports were identified from PubMed, Cochrane Library and CBM-disc (China Biological Medicine Database) on 1 May 2013, and eligible studies were recruited and synthesized to identifying patterns among study results. T869C TT genotype in the overall population was associated with increased RA risk (OR = 1.28, 95% CI: 1.02-1.60, p = 0.03). In the sub-group analysis, T869C TT genotype was shown to be a risk factor for RA, and T869C C allele or CC genotype a protective factor against RA disease in Asians, but these associations were not found in Caucasians. Furthermore, TGFβ1 C509T TT genotype was distinctly associated with RA susceptibility, but the T allele and CC genotype were not. TGFβ1 G915C gene polymorphism was not associated with RA susceptibility. In conclusion, the TT genotype of TGFβ1 T869C was associated with RA risk in the overall population and Asians. Furthermore, CC genotype or C allele was determined to be protective factors with respect to the RA risk in the overall population and Asians. Nonetheless, additional studies are required to firmly establish a correlation between the aforementioned polymorphisms and RA risk.
转化生长因子-β1（TGFβ1）相关联是涉及细胞外基质调节的重要信号通路因子，其基因多态性与类风湿关节炎（RA）风险的关系目前仍存在激烈争论。因此，进行了这项荟萃分析，以确定TGFβ1 T869C、G915C和C509T基因多态性是否与患RA的风险相关。2013年5月1日从PubMed、Cochrane图书馆和中国生物医学数据库（CBM-disc）中检索相关关联报告，纳入并综合符合条件的研究以识别研究结果中的模式。总体人群中T869C TT基因型与RA风险增加相关（OR = 1.28，95% CI：1.02 - 1.60，p = 0.03）。亚组分析显示，T869C TT基因型是亚洲人患RA的危险因素，而T869C C等位基因或CC基因型是预防RA疾病的保护因素，但在高加索人中未发现这些关联。此外，TGFβ1 C509T TT基因型与RA易感性明显相关，但T等位基因和CC基因型则不然。TGFβ1 G915C基因多态性与RA易感性无关。总之，TGFβ1 T869C的TT基因型与总体人群及亚洲人的RA风险相关。此外，CC基因型或C等位基因被确定为总体人群及亚洲人RA风险的保护因素。尽管如此，仍需要更多研究来确定上述多态性与RA风险之间的关联。
