转化生长因子-β1基因G915C、G800A、C509T多态性与糖尿病肾病风险关联的荟萃分析。
A meta-analysis of the association of G915C, G800A, C509T gene polymorphism of transforming growth factor-β1 with diabetic nephropathy risk.
作者信息
Zhang Jie, Guan Ya-Li, Xiao Yan, Zhang Xian-Wen
机构信息
Department of Endocrinology, Central Hospital of People's Liberation Army , Zhengzhou , China .
出版信息
Ren Fail. 2014 Mar;36(2):321-6. doi: 10.3109/0886022X.2013.832320. Epub 2013 Sep 24.
This meta-analysis was conducted to evaluate the association of transforming growth factor-β1 (TGF-β1) G915C, G800A, C509T gene polymorphism with the risk of diabetic nephropathy (DN). The association literatures were identified from PubMed, Cochrane Library, and CBM-disc (China Biological Medicine Database) on March 1, 2013, and eligible reports were recruited and synthesized. Seven reports were recruited into this meta-analysis for the association of TGF-β1 G800A, C509T, G915C gene polymorphism with DN risk. GG genotype, CC genotype, and C allele of TGF-β1 G915C were not associated with the DN risk (GG: OR = 0.84, 95% CI: 0.62-1.14, p = 0.27; CC: OR = 1.05, 95% CI: 0.50-2.22, p = 0.90; C allele: OR = 1.16, 95% CI: 0.88-1.51, p = 0.29). Furthermore, TGF-β1 G800A, C509T gene polymorphism was not associated with the DN risk. In conclusion, TGF-β1 G915C, G800A, and C509T gene polymorphism are not associated with the DN risk. However, more studies should be performed to confirm this relationship in the future.
本荟萃分析旨在评估转化生长因子-β1（TGF-β1）G915C、G800A、C509T基因多态性与糖尿病肾病（DN）风险的相关性。于2013年3月1日从PubMed、Cochrane图书馆和中国生物医学数据库（CBM-disc）中检索相关关联文献，并纳入符合条件的报告进行综合分析。本荟萃分析纳入了7篇关于TGF-β1 G800A、C509T、G915C基因多态性与DN风险相关性的报告。TGF-β1 G915C的GG基因型、CC基因型和C等位基因与DN风险无关（GG：OR = 0.84，95%CI：0.62 - 1.14，p = 0.27；CC：OR = 1.05，95%CI：0.50 - 2.22，p = 0.90；C等位基因：OR = 1.16，95%CI：0.88 - 1.51，p = 0.29）。此外，TGF-β1 G800A、C509T基因多态性与DN风险无关。总之，TGF-β1 G915C、G800A和C509T基因多态性与DN风险无关。然而，未来需要更多研究来证实这种关系。
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