Department of Rehabilitation and Movement Sciences, Rutgers Biomedical and Health Sciences, Newark, New Jersey, U.S.A.
cBRAIN, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany.
J Clin Neurophysiol. 2023 Jul 1;40(5):398-407. doi: 10.1097/WNP.0000000000000864. Epub 2023 Mar 16.
Sport-related concussion (SRC) affects an estimated 1.6 to 3.8 million Americans each year. Sport-related concussion results from biomechanical forces to the head or neck that lead to a broad range of neurologic symptoms and impaired cognitive function. Although most individuals recover within weeks, some develop chronic symptoms. The heterogeneity of both the clinical presentation and the underlying brain injury profile make SRC a challenging condition. Adding to this challenge, there is also a lack of objective and reliable biomarkers to support diagnosis, to inform clinical decision making, and to monitor recovery after SRC. In this review, the authors provide an overview of advanced neuroimaging techniques that provide the sensitivity needed to capture subtle changes in brain structure, metabolism, function, and perfusion after SRC. This is followed by a discussion of emerging neuroimaging techniques, as well as current efforts of international research consortia committed to the study of SRC. Finally, the authors emphasize the need for advanced multimodal neuroimaging to develop objective biomarkers that will inform targeted treatment strategies after SRC.
运动相关性脑震荡（SRC）每年影响估计 160 万至 380 万美国人。运动相关性脑震荡是由于头部或颈部的生物力学力导致广泛的神经症状和认知功能障碍。尽管大多数人在数周内康复，但有些人会出现慢性症状。临床表现和潜在的脑损伤特征的异质性使得 SRC 成为一种具有挑战性的疾病。此外，缺乏客观和可靠的生物标志物来支持诊断、为临床决策提供信息以及监测 SRC 后的恢复情况。在这篇综述中，作者概述了先进的神经影像学技术，这些技术提供了捕捉 SRC 后大脑结构、代谢、功能和灌注细微变化所需的灵敏度。接下来讨论了新兴的神经影像学技术，以及致力于 SRC 研究的国际研究联盟的当前努力。最后，作者强调需要先进的多模态神经影像学来开发客观的生物标志物，以便在 SRC 后为有针对性的治疗策略提供信息。
