McDonald S W, Scothorne R J
Department of Anatomy, University of Glasgow.
J Anat. 1986 Feb;144:49-59.
The histological response of the regional testicular lymph node has been studied at intervals from 1-12 weeks after unilateral vasectomy in rats. The criteria of a humoral immune response were increase in volume of the node, of number and size of germinal centres and of thickness and cellularity of medullary cords. Histological evidence of an immune response was delayed and variable, in conformity with serological data. Variability in the lymphatic drainage of the testis and epididymis has not been finally excluded as a cause of this variation in response. Variability of response did not seem to correlate with variation in site and size of the sperm granuloma, which is thought to be the principal site of leakage of sperm antigens.
在大鼠单侧输精管结扎术后1至12周的不同时间间隔，对局部睾丸淋巴结的组织学反应进行了研究。体液免疫反应的标准包括淋巴结体积增加、生发中心数量和大小增加、髓索厚度和细胞数量增加。免疫反应的组织学证据出现延迟且存在差异，这与血清学数据一致。睾丸和附睾淋巴引流的变异性作为这种反应差异的一个原因尚未被最终排除。反应的变异性似乎与精子肉芽肿的部位和大小的变化无关，而精子肉芽肿被认为是精子抗原泄漏的主要部位。
