Department of General Surgery, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China.
Eur Rev Med Pharmacol Sci. 2023 Mar;27(5):2052-2059. doi: 10.26355/eurrev_202303_31576.
Hepatocellular carcinoma (HCC) is the sixth leading cause of malignant tumors worldwide. Liver resection is a pivotal treatment modality for HCC. Surgical margin plays an important role in decreasing recurrence and improving prognosis for HCC patients.
This paper aimed to perform a systematic review of the literature in regard to surgical margin in HCC patients with microvascular invasion (MVI).
Residual MVI due to insufficient surgical margins is the main origin of postoperative recurrence and metastasis in HCC patients. A wide surgical margin (WSM) significantly improves oncological outcomes and long-term survival in HCC patients with MVI. Progress in the preoperative prediction of MVI may contribute to precise surgical decision-making in the future.
WSM was associated with better outcomes in HCC patients with MVI. WSM is recommended for well-preserved liver function HCC patients who are predicted to have a high risk of MVI preoperatively.
肝细胞癌（HCC）是全球第六大常见恶性肿瘤。肝切除术是 HCC 的主要治疗方式。手术切缘在降低 HCC 患者复发率和改善预后方面发挥着重要作用。
本文旨在对伴有微血管侵犯（MVI）的 HCC 患者的手术切缘进行系统的文献回顾。
由于手术切缘不足导致的残留 MVI 是 HCC 患者术后复发和转移的主要原因。宽切缘（WSM）可显著改善伴有 MVI 的 HCC 患者的肿瘤学结局和长期生存。MVI 术前预测的进展可能有助于未来的精确手术决策。
WSM 与伴有 MVI 的 HCC 患者的较好结局相关。对于术前预测 MVI 风险较高且肝功能良好的 HCC 患者，建议采用 WSM。
