Ohara S, Takahashi H, Ikuta F
Department of Experimental Neuropathology, Niigata University, Japan.
J Anat. 1986 Oct;148:77-85.
Wallerian degeneration was induced by crushing the mouse phrenic nerve at the neck. During a chronological study, a specialised cell contact was often observed between the activated endoneurial fibroblast and the macrophage at the period when the removal of myelin debris by macrophages was prominent in the endoneurium. The specialised contact was characterised by paired subplasmalemmal linear condensations with a relatively constant thickness and varied length. It was sometimes asymmetrical. In these specialised cell membrane areas the intercellular space was filled with fine granular material showing a midline denser stratum. Coated vesicles were occasionally found in association with the subplasmalemmal densities. The specialised contacts with these features are quite different from any type of previously described cell contact between fibroblasts but are morphologically identical to those reported between cells of the mononuclear phagocytotic system. The significance of specialised contacts between the fibroblasts and macrophages in Wallerian degeneration is discussed.
通过在颈部挤压小鼠膈神经诱导沃勒变性。在一项时间顺序研究中，在内神经膜中巨噬细胞清除髓磷脂碎片显著的时期，经常观察到活化的神经内膜成纤维细胞与巨噬细胞之间存在一种特殊的细胞接触。这种特殊接触的特征是成对的亚质膜线性凝聚物，厚度相对恒定，长度各异。它有时不对称。在这些特殊的细胞膜区域，细胞间隙充满了细颗粒物质，显示出一条中线较致密的层。偶尔会发现包被小泡与亚质膜密度相关。具有这些特征的特殊接触与先前描述的成纤维细胞之间的任何类型的细胞接触都有很大不同，但在形态上与单核吞噬系统细胞之间报道的接触相同。本文讨论了沃勒变性中成纤维细胞与巨噬细胞之间特殊接触的意义。
