针对肠道细菌毒力抗原的分泌型IgA抗体：其诱导及可能的相关性

Secretory IgA antibodies to enterobacterial virulence antigens: their induction and possible relevance.

Hanson L A, Ahlstedt S, Carlsson B, Kaijser B, Larsson P, Baltzer I M, Akerlund A S, Edén C S, Svennerholm A M

Adv Exp Med Biol. 1978;107:165-76. doi: 10.1007/978-1-4684-3369-2_20.

Abstract

Milk and salivary s-IgA antibodies are via the homing of IgA producing cells from the Peyer's patches closely connected with antigenic stimuli in the intestine. This explains the presence in human milk of s-IgA antibodies against E. coli O and K antigens, V. cholerae and Shigella O antigens, E. coli and V. cholerae enterotoxins. These secretory antibodies can be induced by intestinal exposure and boosted by parenteral vaccination. 2) Preliminary data suggest that the IgA response in the urinary tract and possibly in the lung may be involved in the homing mechanism as well. 3) The protective role of the milk s-IgA antibodies to enterobacterial virulence antigens is strongly suggested, as is the protection mediated by urinary antibodies against urinary tract infections.

摘要

乳汁和唾液中的分泌型免疫球蛋白A（s-IgA）抗体是通过派尔集合淋巴结中产生IgA的细胞归巢作用，与肠道中的抗原刺激紧密相连。这就解释了人乳中存在针对大肠杆菌O和K抗原、霍乱弧菌和志贺氏菌O抗原、大肠杆菌和霍乱弧菌肠毒素的s-IgA抗体。这些分泌性抗体可通过肠道接触诱导产生，并通过非肠道疫苗接种得到增强。2) 初步数据表明，泌尿道以及可能肺部的IgA反应可能也参与了归巢机制。3) 强烈提示乳汁s-IgA抗体对肠杆菌毒力抗原具有保护作用，尿液抗体对尿路感染介导的保护作用也是如此。