Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Immunology, University Hospital Zurich, Zurich, Switzerland.
Curr Opin Immunol. 2023 Jun;82:102300. doi: 10.1016/j.coi.2023.102300. Epub 2023 Mar 15.
After many years of a niche research in a few laboratories of the world, T-betCD21 B cells have entered the limelight during the last years after the discovery of T-bet as common transcription factor of this unconventional B cell population and the increasing awareness of the expansion of these cells in autoimmune and infectious diseases. This population consists of different subsets which share large parts of their transcriptome, essential phenotypic markers, and reduced B cell receptor (BCR) signaling capacity. Inborn errors of immunity have helped to delineate essential signals for their differentiation. While our comprehension of their origin has improved, future research will hopefully profit from a common definition of the different T-betCD21 subpopulations in order to better define their specific roles during normal and aberrant immune responses.
经过多年在世界上少数几个实验室的专门研究，T-betCD21 B 细胞在发现 T-bet 作为这种非常规 B 细胞群体的共同转录因子以及越来越意识到这些细胞在自身免疫和传染病中的扩增之后，近年来成为焦点。该群体由不同的亚群组成，这些亚群共享其转录组、重要表型标记物和降低的 B 细胞受体 (BCR) 信号转导能力的大部分。先天性免疫缺陷有助于描绘其分化的基本信号。尽管我们对其起源的理解有所提高，但未来的研究有望从不同 T-betCD21 亚群的共同定义中受益，以更好地定义它们在正常和异常免疫反应中的特定作用。
