迷幻剂：临床前研究的启示为未来研究指明了方向。
Psychedelics: preclinical insights provide directions for future research.
机构信息
Department of Pharmacology, UNC School of Medicine, Chapel Hill, NC, 27514, USA.
出版信息
Neuropsychopharmacology. 2024 Jan;49(1):119-127. doi: 10.1038/s41386-023-01567-7. Epub 2023 Mar 17.
Abstract
Recently, psychedelics have emerged as promising therapeutics for numerous neuropsychiatric disorders. While their potential in the clinic has yet to be fully elucidated, understanding their molecular and biological mechanisms is imperative as these compounds are becoming widely used both in therapeutic and recreational contexts. This review examines the current understanding of basic biology, pharmacology, and structural biology in an attempt to reveal both the knowns and unknowns within the field.
摘要
最近，迷幻剂已成为许多神经精神疾病有前途的治疗方法。虽然它们在临床上的潜力尚未完全阐明，但了解这些化合物的分子和生物学机制是至关重要的，因为这些化合物在治疗和娱乐方面的应用越来越广泛。本综述检查了基础生物学、药理学和结构生物学的当前理解，试图揭示该领域的已知和未知。
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