学生自杀意念的心理意象试验（MISST）：一项关于开放型情感应对（BMAC）加风险评估与指引与单纯风险评估与指引的可行性随机对照试验的研究方案。

The Mental Imagery for Suicidality in Students Trial (MISST): study protocol for a feasibility randomised controlled trial of broad-minded affective coping (BMAC) plus risk assessment and signposting versus risk assessment and signposting alone.

作者信息

Taylor Peter James, Duxbury Paula, Moorhouse Jane, Russell Chloe, Pratt Dan, Parker Sophie, Sutton Chris, Lobban Fiona, Drake Richard, Eccles Steve, Ryder David, Patel Rafeea, Kimber Elizabeth, Kerry Eirian, Randles Nathan, Kelly James, Palmier-Claus Jasper

机构信息

Division of Psychology & Mental Health, University of Manchester, Manchester, UK.

Manchester Mental Health NHS Foundation Trust, Manchester, UK.

出版信息

Pilot Feasibility Stud. 2023 Mar 17;9(1):43. doi: 10.1186/s40814-023-01273-7.

DOI:10.1186/s40814-023-01273-7

PMID:36932430

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10021063/

Abstract

BACKGROUND

Going to university is an important milestone in many people's lives. It can also be a time of significant challenge and stress. There are growing concerns about mental health amongst student populations including suicide risk. Student mental health and counselling services have the potential to prevent suicide, but evidence-based therapies are required that fit these service contexts. The Broad-Minded Affective Coping intervention (BMAC) is a brief (6 sessions), positive imagery-based intervention that aims to enhance students access to past positive experiences and associated emotions and cognitions. Pilot data provides preliminary support for the BMAC for students struggling with suicidal thoughts and behaviours, but this intervention has not yet been evaluated in the context of a randomised controlled trial (RCT). The Mental Imagery for Suicidality in Students Trial (MISST) is a feasibility RCT that aims to determine the acceptability and feasibility of evaluating the BMAC as an intervention for university students at risk of suicide within a larger efficacy trial. Key feasibility uncertainties have been identified relating to recruitment, retention, and missing data. Intervention acceptability and safety will also be evaluated.

METHOD

MISST is a feasibility randomised controlled trial design, with 1:1 allocation to risk assessment and signposting plus BMAC or risk assessment and signposting alone. Participants will be university students who self-report experiences of suicidal ideation or behaviour in the past 3 months. Assessments take place at baseline, 8, 16, and 24 weeks. The target sample size is 66 participants. A subset of up to 20 participants will be invited to take part in semi-structured qualitative interviews to obtain further data concerning the acceptability of the intervention.

DISCUSSION

The BMAC intervention may provide an effective, brief talking therapy to help university students struggling with suicidal thoughts that could be readily implemented into university student counselling services. Depending on the results of MISST, the next step would be to undertake a larger-scale efficacy trial.

TRIAL REGISTRATION

The trial was preregistered (17 December 2021) on ISRCTN (ISRCTN13621293) and ClinicalTrials.gov (NCT05296538).

摘要

背景

上大学是许多人人生中的一个重要里程碑。这也是一个面临重大挑战和压力的时期。学生群体中的心理健康问题，包括自杀风险，受到越来越多的关注。学生心理健康与咨询服务有预防自杀的潜力，但需要适合这些服务环境的循证疗法。“心胸开阔情感应对”干预措施（BMAC）是一种简短的（6节课程）、基于积极意象的干预措施，旨在增强学生对过去积极经历以及相关情感和认知的获取。试点数据为BMAC对有自杀想法和行为的学生提供了初步支持，但该干预措施尚未在随机对照试验（RCT）的背景下进行评估。“学生自杀意念的心理意象试验”（MISST）是一项可行性随机对照试验，旨在确定在一项更大规模的疗效试验中，将BMAC作为对有自杀风险的大学生的干预措施进行评估的可接受性和可行性。已确定与招募、留存和缺失数据相关的关键可行性不确定性。还将评估干预措施的可接受性和安全性。

方法

MISST采用可行性随机对照试验设计，按1:1分配至风险评估与引导加BMAC组或仅风险评估与引导组。参与者将是在过去3个月内自我报告有自杀意念或行为经历的大学生。评估在基线、第8周、第16周和第24周进行。目标样本量为66名参与者。将邀请最多20名参与者的一个子集参加半结构化定性访谈，以获取有关干预措施可接受性的进一步数据。