Department of Internal Medicine, School of Medicine, Colorectal Research Center, Rasoul-E-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Acta Neurol Belg. 2023 Dec;123(6):2201-2211. doi: 10.1007/s13760-023-02222-0. Epub 2023 Mar 18.
Multiple sclerosis (MS) is the most prevalent neurological disease among young adults. Because of the chronic nature of this disease, it is important to assess quality of life in these patients. The Multiple Sclerosis Quality of Life -29 (MSQOL-29) questionnaire which contains two main scales, Physical Health Composite (PHC) and Mental Health Composite (MHC), has been designed for this goal. The purpose of the present study is to translate and validate a Persian version of MSQOL-29 (P-MSQOL-29).
Using the forward-backward translation method, a panel of experts established the content validity of P-MSQOL-29. It was then administered to 100 patients with MS who also completed the Short Form-12 (SF-12) questionnaire. Cronbach's alpha was used to assess the internal consistency of P-MSQOL-29. Spearman's correlation coefficient was used to analyze the concurrent validity when correlating the items of P-MSQOL-29 to SF-12.
Mean (Standard Deviation) of PHC and MHC for all patients was 51 (16.4), and 58 (23), respectively. Cronbach's alpha was 0.7 for PHC and 0.9 for MHC. Thirty patients completed the questionnaire again after 3-4 weeks, Intraclass Correlation Coeffiecient (ICC) was 0.80 for PHCs and 0.85 for MHCs (both P values < 0.01). A moderate to high correlation was detected between MHC/PHC and the corresponding scales of SF-12 (MHC with Mental Component Score: ρ = 0.55; PHC with Physical Component Score: ρ = 0.77; both P values < 0.01).
P-MSQOL-29 is a valid and reliable questionnaire and can be used for assessing quality of life in patients with MS.
多发性硬化症（MS）是年轻成年人中最常见的神经疾病。由于这种疾病的慢性性质，评估这些患者的生活质量非常重要。多发性硬化症生活质量-29 问卷（MSQOL-29）包含两个主要量表，即身体健康综合评分（PHC）和心理健康综合评分（MHC），旨在实现这一目标。本研究旨在翻译和验证多发性硬化症生活质量-29 问卷的波斯语版本（P-MSQOL-29）。
采用正向-反向翻译法，一组专家确定了 P-MSQOL-29 的内容效度。然后将其应用于 100 名多发性硬化症患者，这些患者还完成了简短形式 12 项健康调查（SF-12）问卷。采用克朗巴赫α系数评估 P-MSQOL-29 的内部一致性。采用斯皮尔曼相关系数分析 P-MSQOL-29 各项目与 SF-12 的相关性。
所有患者的 PHC 和 MHC 的平均值（标准差）分别为 51（16.4）和 58（23）。PHC 的克朗巴赫α系数为 0.7，MHC 的为 0.9。30 名患者在 3-4 周后再次完成了问卷，PHC 的组内相关系数（ICC）为 0.80，MHC 的为 0.85（均 P 值<0.01）。MHC/PHC 与 SF-12 的相应量表之间检测到中等至高度相关性（MHC 与心理成分评分：ρ=0.55；PHC 与生理成分评分：ρ=0.77；均 P 值<0.01）。
P-MSQOL-29 是一种有效且可靠的问卷，可用于评估多发性硬化症患者的生活质量。
