啮齿动物中产仔数的持久阴影：产仔数是一个报道较少的变量，它强烈决定着成年动物的生理机能。
The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology.
机构信息
Institut de Recerca Sant Joan de Déu, SJD-Barcelona Children's Hospital, Endocrine Division, Esplugues, Barcelona, Spain.
Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, Inserm UMR-S1172, F-59000, Lille, France.
出版信息
Mol Metab. 2023 May;71:101707. doi: 10.1016/j.molmet.2023.101707. Epub 2023 Mar 16.
Abstract
BACKGROUND/PURPOSE: Litter size is a biological variable that strongly influences adult physiology in rodents. Despite evidence from previous decades and recent studies highlighting its major impact on metabolism, information about litter size is currently underreported in the scientific literature. Here, we urge that this important biological variable should be explicitly stated in research articles.
RESULTS/CONCLUSION: Below, we briefly describe the scientific evidence supporting the impact of litter size on adult physiology and outline a series of recommendations and guidelines to be implemented by investigators, funding agencies, editors in scientific journals, and animal suppliers to fill this important gap.
摘要
背景/目的：胎仔数是一个强烈影响啮齿动物成年生理学的生物学变量。尽管之前几十年的研究证据和最近的研究都强调了它对代谢的重大影响，但目前科学文献中对胎仔数的报道较少。在这里，我们强烈要求在研究论文中明确说明这一重要的生物学变量。
结果/结论：下文简要描述了支持胎仔数对成年生理学影响的科学证据，并概述了一系列建议和指南，供研究人员、资助机构、科学期刊编辑和动物供应商实施，以填补这一重要空白。
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