个体化镇静在急性脑损伤患者中的应用。

Toward individualized sedation in patients with acute brain damage.

机构信息

Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, F-38000, Grenoble, France; Univ. Grenoble Alpes, Inserm, U1216, Grenoble Alpes University Hospital, Grenoble Institut Neurosciences, F-38000 Grenoble, France.

Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, F-38000, Grenoble, France.

出版信息

Anaesth Crit Care Pain Med. 2023 Aug;42(4):101219. doi: 10.1016/j.accpm.2023.101219. Epub 2023 Mar 16.

DOI:10.1016/j.accpm.2023.101219

PMID:36933799

Abstract

Sedation/analgesia in patients with acute brain damage, either traumatic or non-traumatic, is paramount to prevent alterations in brain perfusion secondary to the injury. Despite reviews on sedative and analgesic drugs, adequate sedation is an overlooked therapy in the prevention and treatment of intracranial hypertension. When to indicate continued sedation? How to guide the level of sedation? How to terminate sedation? This narrative review provides a practical approach to the individualized use of sedative/analgesic drugs in patients with acute brain damage.

摘要

急性脑损伤（无论是创伤性还是非创伤性）患者的镇静/镇痛至关重要，可预防损伤导致的脑灌注改变。尽管有关于镇静和镇痛药物的综述，但在预防和治疗颅内压升高方面，充分的镇静治疗常常被忽视。何时需要持续镇静？如何指导镇静水平？如何终止镇静？本叙述性综述为急性脑损伤患者个体化使用镇静/镇痛药物提供了一种实用方法。