Meryon S D
Department of Oral Pathology, Dental School, St. Chad's Queensway, Birmingham, United Kingdom.
J Biomed Mater Res. 1987 Oct;21(10):1179-86. doi: 10.1002/jbm.820211002.
In the toxicity testing of dental materials the quantity of material used may have a profound influence on the biological response obtained. This was investigated in vitro by assessing the cytotoxicity of equal volumes of nine materials in artificial cavities of three different diameters, chosen to cover the range found in vivo. With seven materials there was a significant increase in toxicity with increasing surface area. The pattern of response of different materials within specific groups was fairly uniform. The degree of toxicity of the test materials relative to controls was also investigated. From the data obtained it is apparent that the maximum cavity diameter appropriate for the material under test must be considered when evaluating the toxicity of dental materials.
在牙科材料的毒性测试中，所用材料的量可能会对所获得的生物学反应产生深远影响。通过评估三种不同直径的人工窝洞中相等体积的九种材料的细胞毒性，在体外对此进行了研究，所选直径范围涵盖了体内发现的范围。对于七种材料，随着表面积的增加，毒性显著增加。特定组内不同材料的反应模式相当一致。还研究了测试材料相对于对照的毒性程度。从获得的数据来看，在评估牙科材料的毒性时，显然必须考虑适合被测材料的最大窝洞直径。
