血浆细胞外囊泡和无细胞线粒体 DNA 与治疗后老年 HIV 感染者的认知功能障碍相关。
Plasma extracellular vesicles and cell-free mitochondrial DNA are associated with cognitive dysfunction in treated older adults with HIV.
机构信息
Division of Infectious Diseases, Weill Cornell Medicine, 525 E. 68th St, Baker Tower, F2331, NY, 10065, New York, USA.
Vitalant Research Institute, San Francisco, CA, 94118, USA.
出版信息
J Neurovirol. 2023 Apr;29(2):218-224. doi: 10.1007/s13365-023-01122-6. Epub 2023 Mar 18.
Abstract
Extracellular vesicles (EVs) are nanoparticles with a role in intercellular communication. Cell-free mitochondrial DNA (cf-mtDNA) has been associated with cognitive dysfunction in people with HIV (PWH). We conducted a nested case-control study to test the hypothesis that plasma EVs are associated with cf-mtDNA and cognitive dysfunction in older PWH. A machine learning-based model identified total EVs, including select EV subpopulations, as well as urine cf-mtDNA and 4-meter walk time carry power to predict the neurocognitive impairment. These features resulted in an AUC-ROC of 0.845 + / - 0.109 (0.615, 1.00).
摘要
细胞外囊泡 (EVs) 是一种在细胞间通讯中起作用的纳米颗粒。无细胞线粒体 DNA (cf-mtDNA) 与 HIV 感染者 (PWH) 的认知功能障碍有关。我们进行了一项巢式病例对照研究，以检验血浆 EVs 与 cf-mtDNA 和老年 PWH 认知功能障碍相关的假设。基于机器学习的模型确定了总 EVs，包括选择的 EV 亚群，以及尿 cf-mtDNA 和 4 米步行时间携带的能力来预测神经认知障碍。这些特征导致 AUC-ROC 为 0.845 + / - 0.109 (0.615, 1.00)。
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