Smell & Taste Clinic, Depatrment of Otrohinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstarsse 74, 01307 Dresden, Germany.
Smell & Taste Clinic, Depatrment of Otrohinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstarsse 74, 01307 Dresden, Germany; Functional Image Processing Laboratory, Department of Radiology, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Cheras, Kuala Lumpur 56000, Malaysia; Department of Radiology and Intervency, Hospital Pakar Kanak-Kanak (Specialist Children Hospital), University Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Neuroscience. 2023 May 21;519:31-37. doi: 10.1016/j.neuroscience.2023.03.017. Epub 2023 Mar 18.
The present study aimed to investigate the relationship between olfactory sulcus (OS) depth and olfactory function considering age and gender and to provide normative data on OS depth in a population with normal olfactory function.
OS depth was obtained using T1 magnetic resonance imaging scans. Participants (mean age ± sd = 57 ± 16 years, ranging from 20 to 80 years) were screened for olfactory function using the Sniffin' Sticks Screening 12 test. They were divided into an olfactory dysfunction group (n = 604) and a normosmia group (n = 493). Participants also completed questionnaires measuring depression, anxiety and quality of life.
The right OS was deeper than the left side in all age groups. On the left side, women had deeper OS compared with men, exhibiting a higher degree of symmetry in left and right OS depth in women. Variance of olfactory function was largely determined by age, OS depth explained only minor portions of this variance. Normative data for minimum OS depth was 7.55 mm on the left and 8.78 mm on the right for participants aged between 18 and 35 years (n = 144), 6.47 mm on the left and 6.99 mm on the right for those aged 36-55 years (n = 120), and 5.28 mm on the left and 6.19 mm on the right for participants older than 55 years (n = 222).
Considering the limited resolution of the presently used T1 weighted MR scans and the nature of the olfactory screening test, OS depth explained only minor portions of the variance of olfactory function, which was largely determined by age. Age-related normative data of OS depth are presented as a reference for future work.
本研究旨在探讨嗅觉沟（OS）深度与嗅觉功能之间的关系，同时考虑年龄和性别因素，并为嗅觉功能正常的人群提供 OS 深度的正常参考值。
使用 T1 磁共振成像扫描获取 OS 深度。通过嗅觉识别测试（Sniffin' Sticks Screening 12）筛选参与者的嗅觉功能，参与者的年龄（平均值±标准差=57±16 岁，范围 20-80 岁）。将参与者分为嗅觉障碍组（n=604）和嗅觉正常组（n=493）。参与者还完成了评估抑郁、焦虑和生活质量的问卷。
在所有年龄组中，右侧 OS 均比左侧深。在左侧，女性 OS 比男性深，女性左右 OS 深度的对称性更高。嗅觉功能的方差主要由年龄决定，OS 深度仅解释了该方差的一小部分。18-35 岁参与者的左侧和右侧 OS 最小深度的正常参考值分别为 7.55mm 和 8.78mm（n=144），36-55 岁参与者的左侧和右侧 OS 最小深度的正常参考值分别为 6.47mm 和 6.99mm（n=120），55 岁以上参与者的左侧和右侧 OS 最小深度的正常参考值分别为 5.28mm 和 6.19mm（n=222）。
考虑到目前使用的 T1 加权磁共振扫描的分辨率有限，以及嗅觉筛查测试的性质，OS 深度仅解释了嗅觉功能方差的一小部分，而这主要由年龄决定。本文提供了 OS 深度的年龄相关性正常参考值，以供未来研究参考。
