偏头痛患者的嗅球体积和嗅沟深度：一项MRI评估
Olfactory bulbus volume and olfactory sulcus depth in migraine patients: an MRI evaluation.
作者信息
Doğan Adil, Bayar Muluk Nuray, Şahan Mehmet Hamdi, Asal Neşe, Inal Mikail, Ergün Ufuk
机构信息
Faculty of Medicine, Radiology Department, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Faculty of Medicine, ENT Department, Kırıkkale University, Kırıkkale, Turkey.
出版信息
Eur Arch Otorhinolaryngol. 2018 Aug;275(8):2005-2011. doi: 10.1007/s00405-018-5029-x. Epub 2018 Jun 6.
OBJECTIVES
To compare the measurements of olfactory bulb volume and olfactory sulcus depth in patients with migraine and a control group.
METHODS
The study included the cranial MRI (1.5 T) images of 200 adults diagnosed with migraine and a control group of 100 subjects without migraine. The control group mainly consisted of the patients with non-migraneous headache. The measurements were obtained from coronal T2-weighted images for standard olfactory bulb (OB) volume and olfactory sulcus (OS) depth.
RESULTS
The OB volume and OS depth values were lower in the migraine group than in the control group. In the migraine group, left OB volume of the males was significantly lower than those of the females. In both the migraine and control groups separately, the left-side OB volume values and the right side OS depth values were significantly greater than those of the contralateral side. There were positive correlations between right and left OB volume, and right and left OS depth values. No change was seen in OB volume and OS depth values according to gender. In older patients, a decrease was determined in the right and left OB volume, and the left-side OS depth values. There was a negative correlation between osmophobia and OB volume values. In migraine patients with osmophobia, the OB volume values were significantly decreased.
CONCLUSION
OB volume values were lower in migraine patients. When osmophobia was present, the OB volume was lower than that of the non-osmophobia migraine patients. Olfactory function monitoring with olfactory tests and olfactory volume monitoring on MRI can be recommended for all migraine patients to diagnose olfactory dysfunction earlier, especially those with osmophobia. Because their OB volume values were detected as lower than those of the migraine patients without osmophobia, it may be thought that blood flow changes and osmophobia may affect the olfactory bulb volume shrinkage in migraine patients.
目的
比较偏头痛患者与对照组嗅球体积和嗅沟深度的测量结果。
方法
本研究纳入了200例诊断为偏头痛的成年人的头颅MRI（1.5T）图像以及100例无偏头痛的对照组受试者。对照组主要由非偏头痛性头痛患者组成。测量是从冠状位T2加权图像中获取标准嗅球（OB）体积和嗅沟（OS）深度。
结果
偏头痛组的OB体积和OS深度值低于对照组。在偏头痛组中，男性的左侧OB体积显著低于女性。在偏头痛组和对照组中，左侧OB体积值和右侧OS深度值均显著大于对侧。左右OB体积之间以及左右OS深度值之间存在正相关。OB体积和OS深度值未因性别而发生变化。在老年患者中，左右OB体积以及左侧OS深度值均有所下降。恐嗅与OB体积值之间存在负相关。在有恐嗅的偏头痛患者中，OB体积值显著降低。
结论
偏头痛患者的OB体积值较低。当存在恐嗅时，OB体积低于无恐嗅的偏头痛患者。对于所有偏头痛患者，建议通过嗅觉测试进行嗅觉功能监测以及在MRI上进行嗅觉体积监测，以便更早地诊断嗅觉功能障碍，尤其是那些有恐嗅的患者。由于发现他们的OB体积值低于无恐嗅的偏头痛患者，可能认为血流变化和恐嗅可能会影响偏头痛患者的嗅球体积缩小。
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