Figueiredo Antonio, Cheer Joseph F
Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Exp Neurol. 2023 Jun;364:114384. doi: 10.1016/j.expneurol.2023.114384. Epub 2023 Mar 17.
Over the past few decades, tremendous work has been dedicated to understanding how cannabinoids, both endogenous and exogenous, impact the process of learning and memory. Here we attempt to summarize the breadth of this research investigating the role of cannabinoid signaling on episodic or hippocampus-dependent memory. This review will focus primarily on studies using pharmacological approaches, allowing us to discuss the impact of cannabinoids at different phases of the memory formation process. We will briefly provide an overview of the endocannabinoid system and the mechanisms underlying memory formation, then discuss the impact of cannabinoids on memory encoding, consolidation, retrieval, and extinction. Additionally, we examine the impact of cannabinoids on synaptic plasticity and intracellular signaling within the hippocampus related to these processes.
在过去几十年里，人们投入了大量工作来了解内源性和外源性大麻素如何影响学习和记忆过程。在此，我们试图总结这项研究的广度，该研究调查了大麻素信号在情景记忆或海马体依赖记忆中的作用。本综述将主要关注使用药理学方法的研究，以便我们讨论大麻素在记忆形成过程不同阶段的影响。我们将简要概述内源性大麻素系统以及记忆形成的潜在机制，然后讨论大麻素对记忆编码、巩固、检索和消退的影响。此外，我们研究大麻素对与这些过程相关的海马体内突触可塑性和细胞内信号传导的影响。
