III型肠化生在预测胃癌风险中的价值有限。
Limited value of type III intestinal metaplasia in predicting risk of gastric carcinoma.
作者信息
Ramesar K C, Sanders D S, Hopwood D
机构信息
Department of Pathology, Ninewells Hospital and Medical School, Dundee, Scotland.
出版信息
J Clin Pathol. 1987 Nov;40(11):1287-90. doi: 10.1136/jcp.40.11.1287.
Abstract
Endoscopic gastric biopsy specimens taken in 1976 from 174 patients were reviewed. Biopsy specimens from 44 patients showed intestinal metaplasia, and subtyping by mucin histochemistry showed that 16 were of type I, 14 of type II, and 14 of type III. Only two of these 174 patients developed gastric adenocarcinoma over the next 10 to 11 years: one with type II and one with type III intestinal metaplasia. Case notes of a separate group of 68 patients with gastric adenocarcinoma diagnosed in 1985 were reviewed for evidence of intestinal metaplasia in a previous gastric biopsy. Only two patients had previously been biopsied; one of these biopsy specimens showed type II intestinal metaplasia and the other showed no intestinal metaplasia. These findings suggest that subtyping of intestinal metaplasia in endoscopic gastric biopsy specimens is of only limited value in identifying patients at risk of gastric adenocarcinoma who require long term follow up.
摘要
对1976年从174例患者身上获取的内镜胃活检标本进行了回顾。44例患者的活检标本显示有肠化生，通过黏液组织化学进行亚型分类显示，16例为I型，14例为II型，14例为III型。在接下来的10至11年里，这174例患者中只有2例发生了胃腺癌：1例为II型肠化生，1例为III型肠化生。对1985年诊断的另一组68例胃腺癌患者的病历进行回顾，以寻找先前胃活检中肠化生的证据。只有2例患者先前接受过活检；其中1例活检标本显示为II型肠化生，另1例未显示肠化生。这些发现表明，内镜胃活检标本中肠化生的亚型分类在识别需要长期随访的胃腺癌高危患者方面价值有限。
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