胰高血糖素与硫酸阿托品对胃排空影响的比较。

Comparison of the effects of glucagon and atropine sulfate on gastric emptying.

作者信息

Chernish S M, Brunelle R R, Rosenak B D, Ahmadzai S

出版信息

Am J Gastroenterol. 1978 Dec;70(6):581-6.

Abstract

Six asymptomatic adult males cooperated in a study of gastric emptying. Each subject was given a test meal of 500 ml. of 3.5% glucose on a fasting stomach. Ten minutes prior to the meal each was given either 1 mg atropine sulfate, placebo, or 2 mg. glucagon, double-blind and crossover. Each drug was given twice, intravenously, in a random order. The meal was removed by a Salem sump tube half an hour after ingestion. When compared to placebo, the active drugs significantly (P less than 0.05) slowed gastric emptying; atropine sulfate was more effective (P less than 0.05) than glucagon. The active drugs significantly (P 0.05) decreased total gastric acid secretion and total gastric chloride as compared to placebo. Glucagon significantly (P 0.05) increased the blood glucose concentration as compared to placebo. These results indicate that both glucagon and atropine sulfate slow the gastric emptying of a liquid sugar meal from the stomach.

摘要

六名无症状成年男性参与了一项胃排空研究。每名受试者在空腹状态下摄入了500毫升3.5%的葡萄糖测试餐。在进餐前十分钟，每名受试者双盲交叉接受1毫克硫酸阿托品、安慰剂或2毫克胰高血糖素，每种药物均通过静脉注射随机给药两次。进食半小时后，用塞勒姆引流管将餐食抽出。与安慰剂相比，活性药物显著（P<0.05）延缓了胃排空；硫酸阿托品比胰高血糖素更有效（P<0.05）。与安慰剂相比，活性药物显著（P<0.05）降低了胃酸总分泌量和胃内氯化物总量。与安慰剂相比，胰高血糖素显著（P<0.05）提高了血糖浓度。这些结果表明，胰高血糖素和硫酸阿托品均可延缓胃内液体糖餐的排空。