循环胰岛素样生长因子-1 与肺部疾病风险：一项孟德尔随机化分析。
Circulating insulin-like growth factor-1 and risk of lung diseases: A Mendelian randomization analysis.
机构信息
Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China.
Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
出版信息
Front Endocrinol (Lausanne). 2023 Mar 3;14:1126397. doi: 10.3389/fendo.2023.1126397. eCollection 2023.
BACKGROUND
Insulin-like growth factor-1 (IGF-1) display a vital role in in the pathogenesis of lung diseases, however, the relationship between circulating IGF-1 and lung disease remains unclear.
METHODS
Single nucleotide polymorphisms (SNPs) associated with the serum levels of IGF-1 and the outcomes data of lung diseases including asthma, chronic obstructive pulmonary disease (COPD), lung cancer and idiopathic pulmonary fibrosis (IPF) were screened from the public genome-wide association studies (GWAS). Two-sample Mendelian randomization (MR) analysis was then performed to assess the independent impact of IGF-1 exposure on these lung diseases.
RESULTS
Totally, 416 SNPs related to circulating IGF-1 levels among 358,072 participants in UK Biobank. According to a primary casual effects model with MR analyses by the inverse variance weighted (IVW) method, the circulating IGF-1 was demonstrated a significantly related with the risk of asthma (OR, 0.992; 95% CI, 0.985-0.999, =0.0324), while circulating IGF-1 showed no significant correlation with CODP (OR, 1.000; 95% CI, 0.999-1.001, =0.758), lung cancer (OR, 0.979, 95% CI, 0.849-1.129, =0.773), as well as IPIGFF (OR, 1.100, 95% CI, 0.794-1.525, =0.568).
CONCLUSION
The present study demonstrated that circulating IGF-1 may be causally related to lower risk of asthma.
背景
胰岛素样生长因子-1（IGF-1）在肺部疾病的发病机制中起着重要作用，但循环 IGF-1 与肺部疾病之间的关系尚不清楚。
方法
从公共全基因组关联研究（GWAS）中筛选与 IGF-1 血清水平相关的单核苷酸多态性（SNP）和包括哮喘、慢性阻塞性肺疾病（COPD）、肺癌和特发性肺纤维化（IPF）在内的肺部疾病的结局数据。然后进行两样本 Mendelian 随机化（MR）分析，以评估 IGF-1 暴露对这些肺部疾病的独立影响。
结果
总共在 UK Biobank 的 358072 名参与者中发现了 416 个与循环 IGF-1 水平相关的 SNP。根据 MR 分析的逆方差加权（IVW）方法的主要因果效应模型，循环 IGF-1 与哮喘的风险呈显著相关（OR，0.992；95%CI，0.985-0.999，=0.0324），而循环 IGF-1 与 COPD（OR，1.000；95%CI，0.999-1.001，=0.758）、肺癌（OR，0.979，95%CI，0.849-1.129，=0.773）和 IPIGFF（OR，1.100，95%CI，0.794-1.525，=0.568）无显著相关性。
结论
本研究表明，循环 IGF-1 可能与哮喘风险降低有关。
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