美国国家癌症研究所天然产物发现计划：利用人工神经网络探索天然产物样品的NCI-60筛选数据。

National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks.

作者信息

Evans Jason R, Akee Rhone K, Chanana Shaurya, McConachie Grant D, Thornburg Christopher C, Grkovic Tanja, O'Keefe Barry R

机构信息

Natural Products Branch, Developmental Therapeutic Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702-1201, United States.

Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, United States.

出版信息

ACS Omega. 2023 Mar 1;8(10):9250-9256. doi: 10.1021/acsomega.2c07416. eCollection 2023 Mar 14.

National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis of natural product high-throughput screening data using the NCI's 60 human tumor cell anticancer drug screen. We demonstrate how the tool enables visualization of similar patterns of response that can be parsed both chemically and taxonomically, grouping NCI-60 biological profiles in one easy-to-use bioinformatics interface.