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长期新冠?新冠病毒感染后缺血性中风和肺栓塞致死病例报告。

Long COVID? Fatal case report of ischemic stroke and pulmonary embolism post COVID-19 infection.

作者信息

Sadiq Abid M, Hassanali Zamina R, Nziku Eliada B, Sadiq Adnan M, Dekker Marieke C J

机构信息

Department of Internal Medicine, Kilimanjaro Christian Medical Centre, P.O. Box 3010, Moshi, Tanzania.

Faculty of Medicine, Kilimanjaro Christian Medical University College, P.O. Box 2240, Moshi, Tanzania.

出版信息

Radiol Case Rep. 2023 Mar 12;18(5):1913-1917. doi: 10.1016/j.radcr.2023.02.022. eCollection 2023 May.

Abstract

Coronavirus disease 19 (COVID-19) may lead to post-COVID syndrome a few weeks to months after the infection with various symptoms. Post-COVID thromboembolic syndrome may be a result of coagulopathy that occurs in both the arterial and venous circulation. Apart from direct cellular infection, post-COVID syndrome may occur due to immune system dysregulation, endothelial injury, and hypercoagulability, leading to thrombosis. We present a 32-year-old man who was diagnosed with mild symptoms of COVID-19 infection 4 months before an acute ischemic stroke and an asymptomatic pulmonary embolism. A COVID-19 antigen test was negative. An analysis of prothrombotic factors was negative. He could not receive any therapeutic intervention before his demise. The extent of COVID-19 infection after the onset of symptoms is a mystery and poses a fatal concern due to the increasing number of complications. The long-term complications after COVID-19 infection are still not understood. Clinicians need to be aware of any signs and symptoms that may arise months after COVID-19 infection and its possible causal relationship.

摘要

新型冠状病毒肺炎(COVID-19)感染数周或数月后可能会引发新冠后综合征,出现各种症状。新冠后血栓栓塞综合征可能是动脉和静脉循环中发生的凝血病所致。除了直接的细胞感染外,新冠后综合征还可能由于免疫系统失调、内皮损伤和高凝状态而发生,进而导致血栓形成。我们报告一名32岁男性,在急性缺血性中风和无症状肺栓塞发生前4个月被诊断为COVID-19感染轻症。COVID-19抗原检测呈阴性。血栓形成前因素分析为阴性。在他去世前未能接受任何治疗干预。症状出现后COVID-19感染的程度仍是个谜,且由于并发症数量不断增加,令人担忧其会带来致命后果。COVID-19感染后的长期并发症仍不清楚。临床医生需要留意COVID-19感染数月后可能出现的任何体征和症状及其可能的因果关系。

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