Kubo Hiroshi, Yamamoto Yorihiro, Fujisawa Akio
School of Bionics, Tokyo University of Technology, 1404-1 Katakura-machi, Hachioji, Tokyo 192-0982, Japan.
Pharmacology & Toxicology Research Team, Bio-Pharma Research Laboratories, Kaneka Corporation, 1-8 Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan.
J Clin Biochem Nutr. 2023 Mar;72(2):101-106. doi: 10.3164/jcbn.22-91. Epub 2022 Dec 8.
Coenzyme Q10 (CoQ10) is an important lipid-soluble antioxidant and an essential component of the mitochondria. The oral bioavailability of the reduced form of CoQ10, ubiquinol-10, has been reported to be greater than that of the oxidized form of CoQ10, ubiquinone-10, in some studies. In contrast, it has also been highlighted that the oral bioavailability of ubiquinol-10 is not superior to that of ubiquinone-10 because ubiquinol-10 may be oxidized during digestion. In fact, it has not been shown which form of CoQ10 exists in the process from oral intake to absorption in the gastrointestinal tract. In this study, the amounts of ubiquinol-10 and ubiquinone-10 were measured in the gastrointestinal content and small intestine tissue after oral administration of ubiquinol-10 or ubiquinone-10 to C57BL/6J mice. The form of CoQ10 detected in the gastrointestinal content and small intestine tissue was almost the same as that when administered orally. The results of our study suggested that the orally administered ubiquinol-10 and ubiquinone-10 mostly reached the small intestine without oxidizing to ubiquinone-10 and reducing to ubiquinol-10, and both were absorbed by the small intestine tissue in almost their original forms.
辅酶Q10（CoQ10）是一种重要的脂溶性抗氧化剂，也是线粒体的重要组成部分。在一些研究中，已报道还原型辅酶Q10（泛醇-10）的口服生物利用度高于氧化型辅酶Q10（泛醌-10）。相比之下，也有人强调泛醇-10的口服生物利用度并不优于泛醌-10，因为泛醇-10在消化过程中可能被氧化。事实上，从口服摄入到在胃肠道吸收的过程中，辅酶Q10以哪种形式存在尚未得到证实。在本研究中，给C57BL/6J小鼠口服泛醇-10或泛醌-10后，测定胃肠道内容物和小肠组织中泛醇-10和泛醌-10的含量。在胃肠道内容物和小肠组织中检测到的辅酶Q10形式与口服给药时几乎相同。我们的研究结果表明，口服的泛醇-10和泛醌-10大多在不氧化为泛醌-10和还原为泛醇-10的情况下到达小肠，并且两者几乎以原始形式被小肠组织吸收。
