Judy William V
Founder and President, SIBR Research.
Integr Med (Encinitas). 2021 Oct;20(5):26-30.
Coenzyme Q10 is one of the most widely sold nutritional supplements in the United States. Coenzyme Q10 is available in both its oxidized form (ubiquinone) and its reduced form (ubiquinol). The predominant marketing of Coenzyme Q10 to physicians and patients asserts that the ubiquinol form of Coenzyme Q10 has superior absorption to the ubiquinone form. This study has been designed to compare and contrast the stability and absorption of ubiquinol supplements, as well as the claims made for ubiquinol compared with ubiquinone.Ubiquinol, the reduced state of Coenzyme Q10, is commercially available as a nutritional supplement; however, ubiquinol, by its nature as an electron donor, is much less stable than ubiquinone, the oxidized state of Coenzyme Q10. The absorption, bioavailability and efficacy of ubiquinol products has been much less often tested in clinical trials. Consequently, insufficiently documented marketing claims are being made for ubiquinol supplements.
In Part 1 of this report on the instability of the lipid-soluble antioxidant ubiquinol, SIBR Research presented data from lab studies showing that oral ubiquinol is likely to be oxidized to ubiquinone and absorbed as ubiquinone. In this Part 2, SIBR Research conducted a study of the transfer and absorption of orally ingested ubiquinol in large dogs.
In the dog studies, the percentage of ubiquinol converted to ubiquinone increased as the capsule contents passed through the stomach and small intestines and into the lymph system.
The dog studies demonstrate that oral ubiquinol in commercial nutritional supplements is not stable in the gastrointestinal tract of large dogs. Based on these results, it seems likely that in humans also, most of the ubiquinol from capsules will be oxidized to ubiquinone in the acid profile between the stomach and the small intestines, where there is a wide range of acidity. The ubiquinol from the supplement will be absorbed in the ubiquinone state and will pass into the lymph system as ubiquinone, where it will be reduced back to ubiquinol. It will pass from the lymph system into the blood circulation as ubiquinol.
辅酶Q10是美国销量最广的营养补充剂之一。辅酶Q10有氧化形式（泛醌）和还原形式（泛醇）两种。向医生和患者进行的辅酶Q10主要营销宣传称，辅酶Q10的泛醇形式比泛醌形式具有更好的吸收性。本研究旨在比较和对比泛醇补充剂的稳定性和吸收情况，以及与泛醌相比泛醇所宣称的优势。泛醇是辅酶Q10的还原态，作为一种营养补充剂在市场上有售；然而，由于其作为电子供体的性质，泛醇比辅酶Q10的氧化态泛醌稳定性要低得多。泛醇产品的吸收、生物利用度和功效在临床试验中的测试要少得多。因此，针对泛醇补充剂的营销宣传缺乏充分的文献记载。
在这份关于脂溶性抗氧化剂泛醇不稳定性报告的第1部分中，SIBR研究公司展示了实验室研究数据，表明口服泛醇很可能被氧化为泛醌并以泛醌形式被吸收。在第2部分中，SIBR研究公司对大型犬口服摄入泛醇的转运和吸收进行了研究。
在犬类研究中，随着胶囊内容物通过胃、小肠并进入淋巴系统，泛醇转化为泛醌的百分比增加。
犬类研究表明，市售营养补充剂中的口服泛醇在大型犬的胃肠道中不稳定。基于这些结果，在人类中似乎也很可能是这样，胶囊中的大多数泛醇在胃和小肠之间酸度范围较宽的酸性环境中会被氧化为泛醌。补充剂中的泛醇将以泛醌状态被吸收，并以泛醌形式进入淋巴系统，在那里它将被还原回泛醇。它将以泛醇形式从淋巴系统进入血液循环。
