Wang Donghao, Ren Yingying, Chen Riken, Zeng Xiangxia, Gan Qiming, Zhuang Zhiyang, Su Xiaofen, Wu Kang, Zhang Sun, Tang Yongkang, Li Shiwei, Zhang Haojie, Zhou Yanyan, Zhang Nuofu, Zhao Dongxing
State Key Laboratory of Respiratory Disease, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, National Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Medical Records and Statistics Room, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Nat Sci Sleep. 2023 Mar 13;15:103-114. doi: 10.2147/NSS.S396695. eCollection 2023.
Obstructive sleep apnea (OSA) is a common sleep-disordered breathing disease. We aimed to establish an improved screening questionnaire without physical examinations for OSA named the CNCQ-OSA (Chinese community questionnaire for OSA).
A total of 2585 participants who visited sleep medicine center and underwent overnight polysomnography were grouped into two independent cohorts: derivation (n = 2180) and validation (n = 405). The CNCQ-OSA was designed according to the baseline of patients in derivation cohort. We comprehensively analyzed the data to evaluate the predictive value of the CNCQ-OSA, compared to the GOAL questionnaire, STOP-Bang questionnaire (SBQ) and NoSAS questionnaire.
The CNCQ-OSA included seven variables: loud snoring, BMI ≥ 25 kg/m, male gender, apnea, sleepiness, hypertension and age ≥30, with a total score ranging from 7 to 16.7 points (≥13.5 points indicating high risk of OSA, ≥14.5 points indicating extremely high risk). In the derivation and validation cohorts, the areas under the curve of the CNCQ-OSA were 0.761 and 0.767, respectively. In the validation cohort, the sensitivity and specificity of a CNCQ-OSA score ≥13.5 points for the apnea-hypopnea index (AHI) ≥5/h were 0.821 and 0.559, respectively (Youden index, 0.380), and the score ≥14.5 points were 0.494 and 0.887, respectively (Youden index, 0.375). The CNCQ-OSA had a better predictive value for AHI ≥ 5/h, AHI > 15/h and AHI > 30/h, with the highest Youden index, compared to the other questionnaires.
The CNCQ-OSA can effectively identify the risk of OSA, which is appropriate for self-screening at home without physical examinations.
阻塞性睡眠呼吸暂停（OSA）是一种常见的睡眠呼吸紊乱疾病。我们旨在建立一种无需体格检查的改良OSA筛查问卷，即CNCQ-OSA（中国社区OSA问卷）。
共有2585名前往睡眠医学中心并接受整夜多导睡眠监测的参与者被分为两个独立队列：推导队列（n = 2180）和验证队列（n = 405）。CNCQ-OSA根据推导队列中患者的基线情况设计。我们综合分析数据以评估CNCQ-OSA的预测价值，并与GOAL问卷、STOP-Bang问卷（SBQ）和NoSAS问卷进行比较。
CNCQ-OSA包括七个变量：大声打鼾、体重指数（BMI）≥25 kg/m²、男性、呼吸暂停、嗜睡、高血压和年龄≥30岁，总分范围为7至16.7分（≥13.5分表示OSA高风险，≥14.5分表示极高风险）。在推导队列和验证队列中，CNCQ-OSA的曲线下面积分别为0.761和0.767。在验证队列中，CNCQ-OSA评分≥13.5分对呼吸暂停低通气指数（AHI）≥5次/小时的敏感性和特异性分别为0.821和0.559（约登指数为0.380），评分≥14.5分的敏感性和特异性分别为0.494和0.887（约登指数为0.375）。与其他问卷相比，CNCQ-OSA对AHI≥5次/小时、AHI>15次/小时和AHI>30次/小时具有更好的预测价值，约登指数最高。
CNCQ-OSA能够有效识别OSA风险，适用于在家中进行自我筛查且无需体格检查。
