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酷似骨肉瘤的椎体动脉瘤样骨囊肿:病例报告及文献复习

Vertebral Aneurysmal Bone Cyst Mimicking Osteosarcoma: Case Report and Review of the Literature.

作者信息

Lechtholz-Zey Elizabeth, Matti Nawar Y, Fredrickson Vance L, Buchanan Ian, Donoho Daniel A

机构信息

Orthopaedic Surgery, Keck School of Medicine of University of South California, Los Angeles, USA.

Pathology, Southwest Healthcare System, Los Angeles, USA.

出版信息

Cureus. 2023 Feb 15;15(2):e35033. doi: 10.7759/cureus.35033. eCollection 2023 Feb.

DOI:10.7759/cureus.35033
PMID:36938191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10023236/
Abstract

Aneurysmal bone cysts are benign osseous lesions containing blood-filled cavities separated by walls of connective tissue. They can be difficult to identify clinically due to similarities in presentation, imaging, and histology with other pathologies. Specifically, it is important to distinguish these benign lesions from malignant processes, as both surgical and medical management differ. We present the case of a 21-year-old patient who presented with impaired motor and sensory function in his lower extremities. Radiologic findings were concerning for an invasive neoplasm, and the intraoperative frozen section supported this conclusion. However, an additional histological investigation was confirmatory for a diagnosis of an aneurysmal bone cyst. The patient underwent corpectomy, laminectomy, and a posterior spinal fusion, and regained motor and sensory function shortly thereafter. This report details the importance of considering aneurysmal bone cysts in the differential of infiltrative bone lesions, despite their benign nature, as medical and surgical management can vary greatly.

摘要

骨囊肿是一种良性骨病变,含有由结缔组织壁分隔的充满血液的腔隙。由于其在临床表现、影像学和组织学上与其他病理情况相似,临床上可能难以识别。具体而言,将这些良性病变与恶性病变区分开来很重要,因为手术和药物治疗方法有所不同。我们报告了一例21岁患者,其下肢运动和感觉功能受损。放射学检查结果提示为侵袭性肿瘤,术中冰冻切片支持这一结论。然而,进一步的组织学检查确诊为骨囊肿。患者接受了椎体切除、椎板切除和后路脊柱融合术,术后不久运动和感觉功能恢复。本报告详细阐述了尽管骨囊肿本质为良性,但在鉴别浸润性骨病变时考虑骨囊肿的重要性,因为药物和手术治疗可能差异很大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4095/10023236/8fcac8c6126c/cureus-0015-00000035033-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4095/10023236/2585f6c4a6e9/cureus-0015-00000035033-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4095/10023236/c81a28a678d8/cureus-0015-00000035033-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4095/10023236/895701dfb419/cureus-0015-00000035033-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4095/10023236/59119197835d/cureus-0015-00000035033-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4095/10023236/8fcac8c6126c/cureus-0015-00000035033-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4095/10023236/2585f6c4a6e9/cureus-0015-00000035033-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4095/10023236/c81a28a678d8/cureus-0015-00000035033-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4095/10023236/895701dfb419/cureus-0015-00000035033-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4095/10023236/59119197835d/cureus-0015-00000035033-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4095/10023236/8fcac8c6126c/cureus-0015-00000035033-i05.jpg

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本文引用的文献

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Aneurysmal bone cyst of the spine in adult patients: A systematic review and comparison of primary vs secondary lesions.成年患者脊柱动脉瘤样骨囊肿:原发性与继发性病变的系统评价及比较
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Current strategies for the treatment of solitary and aneurysmal bone cysts: A review of the literature.孤立性和动脉瘤性骨囊肿的当前治疗策略:文献综述
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The 2020 WHO Classification of Tumors of Bone: An Updated Review.
2020 年世卫组织骨肿瘤分类:更新综述。
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Secondary aneurysmal bone cyst of the spine: Clinicopathological features, surgical modalities and outcomes.脊柱继发性动脉瘤样骨囊肿:临床病理特征、手术方式及疗效。
Clin Neurol Neurosurg. 2020 Jan;188:105595. doi: 10.1016/j.clineuro.2019.105595. Epub 2019 Nov 11.
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Challenges in the Diagnosis and Treatment of Aneurysmal Bone Cyst in Patients with Unusual Features.具有不寻常特征的动脉瘤样骨囊肿患者的诊断和治疗挑战
Adv Orthop. 2019 Aug 4;2019:2905671. doi: 10.1155/2019/2905671. eCollection 2019.
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Denosumab: A potential new treatment option for recurrent Aneurysmal Bone Cyst of the spine.地诺单抗:脊柱复发性动脉瘤样骨囊肿的一种潜在新治疗选择。
SICOT J. 2019;5:10. doi: 10.1051/sicotj/2019007. Epub 2019 Apr 1.
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Percutaneous albumin/doxycycline injection versus open surgery for aneurysmal bone cysts in the mobile spine.经皮白蛋白/强力霉素注射与开放手术治疗活动脊柱动脉瘤样骨囊肿。
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Denosumab: a potential treatment option for aneurysmal bone cyst of the atlas.地诺单抗:寰椎动脉瘤样骨囊肿的一种潜在治疗选择。
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Current Strategies for the Treatment of Aneurysmal Bone Cysts.动脉瘤样骨囊肿的当前治疗策略
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