Levy L J, Bolton R P, Losowsky M S
Department of Medicine, St. James's University Hospital, Leeds, U.K.
J Hepatol. 1987 Oct;5(2):211-7. doi: 10.1016/s0168-8278(87)80575-5.
Visual evoked potential determinations and the number connection test were performed for 49 patients with stable chronic liver disease and portal hypertension but without clinical evidence of hepatic encephalopathy. The latencies of the evoked potential components N2, P2 and N3 were significantly prolonged compared to the controls. Seven patients had a prolonged N2, 10 had a prolonged P2, and 14 patients had a prolonged N3 latency. Only five of these patients had increased theta activity of the electroencephalogram. When age norms were applied, the number connection test was significantly prolonged only in the 16-36-years age group. It is concluded that the visual evoked potential identifies a group of patients with neurophysiological abnormalities and may be useful in identifying those at risk of developing overt encephalopathy.
对49例患有稳定型慢性肝病和门静脉高压但无肝性脑病临床证据的患者进行了视觉诱发电位测定和数字连接测试。与对照组相比，诱发电位成分N2、P2和N3的潜伏期显著延长。7例患者N2潜伏期延长，10例患者P2潜伏期延长，14例患者N3潜伏期延长。这些患者中只有5例脑电图的θ波活动增加。应用年龄标准时，仅在16 - 36岁年龄组中数字连接测试显著延长。结论是视觉诱发电位可识别出一组有神经生理异常的患者，可能有助于识别有发生明显脑病风险的患者。
