Davies M G, Rowan M J, Feely J
Dept. of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland.
Scand J Gastroenterol. 1990 Dec;25(12):1205-14. doi: 10.3109/00365529008998555.
In recent years many variants of EEG sensory evoked responses have been studied as potential diagnostic aids in the detection and quantification of hepatic encephalopathy (HE). This study assesses the value of the flash visual evoked response (VER). Twenty-six controls and 21 non-encephalopathic and 12 encephalopathic (grade 1/2), biopsy-proven, cirrhotic patients were assessed clinically, psychometrically, and electrophysiologically. Flash VER from three different leads were obtained from each patient. Data from the fronto-occipital leads gave the best differentiation between the subjects. The P2 and N3 peak latencies were significantly increased in the two liver groups and correlated with the mental state and psychometric results. The N3 latency had a 92% specificity and a 50% sensitivity in the detection of grade 1/2 HE. This study suggests that the N3 latency changes may be a good marker of early clinical HE and useful in the longitudinal assessment of individual patients.
近年来，脑电图感觉诱发电位的许多变体已被研究，作为检测和量化肝性脑病（HE）的潜在诊断辅助手段。本研究评估闪光视觉诱发电位（VER）的价值。对26名对照者、21名无脑病的患者以及12名经活检证实为肝硬化且患有脑病（1/2级）的患者进行了临床、心理测量和电生理评估。从每位患者身上获取来自三个不同导联的闪光VER。额枕导联的数据在受试者之间显示出最佳的区分度。两个肝病组的P2和N3峰潜伏期显著延长，且与精神状态和心理测量结果相关。N3潜伏期在检测1/2级HE时具有92%的特异性和50%的敏感性。本研究表明，N3潜伏期变化可能是早期临床HE的良好标志物，有助于对个体患者进行纵向评估。
