Casas M, Garcia-Ribera C, Alvarez E, Udina C, Queralto J M, Grau J M
Department of Psychiatry, Hospital de la Santa Creu i Sant Pau (Medical School), Barcelona, Spain.
Int Clin Psychopharmacol. 1987 Oct;2(4):333-6. doi: 10.1097/00004850-198710000-00006.
Myoclonic movements have been observed in depressed patients receiving therapeutic doses of clomipramine. Such movements, which appear in states of deep muscular relaxation such as sleep, do not appear to have any repercussion in the outcome of the depression and are reversible following withdrawal of the drug. In this study the plasma levels of clomipramine and desmethylclomipramine were determined and their possible relationship with myoclonus studied. No statistically significant relationships were found.
在接受治疗剂量氯米帕明的抑郁症患者中观察到了肌阵挛运动。这种运动出现在深度肌肉放松状态下，如睡眠时，似乎对抑郁症的转归没有任何影响，并且在停药后是可逆的。在本研究中，测定了氯米帕明和去甲氯米帕明的血浆水平，并研究了它们与肌阵挛的可能关系。未发现具有统计学意义的关系。
