老年营养风险指数变化与腹膜透析患者死亡率的关系。

The association between geriatric nutritional risk index variability and mortality in peritoneal dialysis patients.

机构信息

Department of Internal Medicine, Division of Nephrology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

Department of Internal Medicine, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

出版信息

Ther Apher Dial. 2023 Aug;27(4):752-759. doi: 10.1111/1744-9987.13984. Epub 2023 Mar 28.

DOI:10.1111/1744-9987.13984

PMID:36938825

Abstract

BACKGROUND

The objective of this study is to examine the association between the Geriatric Nutritional Risk Index (GNRI) and overall mortality in this population.

METHODS

GNRI values were calculated by using the serum albumin levels and body weight and the GNRI variability reflects the changes in GNRI change slopes in the follow-up.

RESULTS

GNRI values showed a decrease from the median baseline GNRI of 106.3 (IQR, 95.0,113.4) to 98.4 (interquartile range [IQR], 91.9108.9) (p < 0.001). The median GNRI variability was 4.7 (IQR, 2.5, 10.3). Both baseline GNRI levels (adjusted odds ratio [OR]: 0.96, 95% confidence interval [CI]: 0.93, 0.99, p = 0.04) and more profoundly GNRI variability (adjusted OR: 1.23, 95% CI: 1.01, 1.44, p = 0.03) were independently associated with mortality.

CONCLUSION

The monitorization of the changes in GNRI values as a variability index is an easy tool that might improve the predictive accuracy of mortality in peritoneal dialysis patients.

摘要

背景

本研究旨在探讨老年营养风险指数（GNRI）与该人群全因死亡率之间的关系。

方法

通过血清白蛋白水平和体重计算 GNRI 值，GNRI 变化率反映了随访期间 GNRI 变化斜率的变化。

结果

GNRI 值从中位数基线 GNRI 106.3（IQR，95.0，113.4）降至 98.4（IQR，91.9-108.9）（p<0.001）。中位数 GNRI 变化率为 4.7（IQR，2.5，10.3）。基线 GNRI 水平（调整后比值比 [OR]：0.96，95%置信区间 [CI]：0.93，0.99，p=0.04）和 GNRI 变化率（调整后 OR：1.23，95% CI：1.01，1.44，p=0.03）均与死亡率独立相关。