Department of Chemistry, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember, Surabaya, Indonesia.
Department of Agrotechnology, Faculty of Natural Science and Engineering Technology, University of Halmahera, Tobelo, North Halmahera, Indonesia.
Nat Prod Res. 2024 Aug;38(15):2697-2702. doi: 10.1080/14786419.2023.2190113. Epub 2023 Mar 20.
In our continuation of exploring antidiabetic agents from species, we found that the methanolic extract of A.C.Sm. exhibited considerable α-glucosidase inhibition of 58.20 ± 0.37% in sucrose substrate and 39.86 ± 2.07% in maltose substrate at 100 μg/mL. Phytochemical investigation on the extract revealed the presence of a new biphenyl, macrabiphenyl A, which was successfully elucidated by means of spectroscopic methods (HRESIMS and 1D and 2D NMR). The α-glucosidase inhibitory evaluation indicated that the new compound was weakly active against the enzyme.
在我们继续从 物种中寻找抗糖尿病药物的过程中，我们发现 A.C.Sm. 的甲醇提取物在 100μg/mL 时对蔗糖底物表现出相当大的α-葡萄糖苷酶抑制作用，为 58.20±0.37%，对麦芽糖底物的抑制作用为 39.86±2.07%。对提取物的植物化学研究表明存在一种新的联苯，即 macrabiphenyl A，通过光谱方法（HRESIMS 和 1D 和 2D NMR）成功阐明了该化合物。α-葡萄糖苷酶抑制评估表明，新化合物对该酶的活性较弱。
