Balusamy Sri Renukadevi, Perumalsamy Haribalan, Huq Md Amdadul, Yoon Tae Hyun, Mijakovic Ivan, Thangavelu Lakshmi, Yang Deok Chun, Rahimi Shadi
Department of Food Science and Biotechnology, Sejong University, Seoul, Gwangjin-gu, Republic of Korea.
Research Institute for Convergence of Basic Science, Hanyang University, Seoul, Republic of Korea.
Med Res Rev. 2023 Sep;43(5):1374-1410. doi: 10.1002/med.21953. Epub 2023 Mar 20.
Among 17 Panax species identified across the world, Panax ginseng (Korean ginseng), Panax quinquefolius (American ginseng), and Panax notoginseng (Chinese ginseng) are highly recognized for the presence of bioactive compound, ginsenosides and their pharmacological effects. P. ginseng is widely used for synthesis of different types of nanoparticles compared to P. quinquefolius and P. notoginseng. The use of nano-ginseng could increase the oral bioavailability, membrane permeability, and thus provide effective delivery of ginsenosides to the target sites through transport system. In this review, we explore the synthesis of ginseng nanoparticles using plant extracts from various organs, microbes, and polymers, as well as their biomedical applications. Furthermore, we highlight transporters involved in transport of ginsenoside nanoparticles to the target sites. Size, zeta potential, temperature, and pH are also discussed as the critical parameters affecting the quality of ginseng nanoparticles synthesis.
在全球已鉴定出的17种人参属植物中，人参（高丽参）、西洋参和三七因其生物活性化合物人参皂苷的存在及其药理作用而备受认可。与人参和三七相比，人参被广泛用于合成不同类型的纳米颗粒。纳米人参的使用可以提高口服生物利用度和膜通透性，从而通过转运系统将人参皂苷有效地递送至靶部位。在本综述中，我们探讨了使用来自各种器官的植物提取物、微生物和聚合物合成人参纳米颗粒及其生物医学应用。此外，我们强调了参与人参皂苷纳米颗粒转运至靶部位的转运体。还讨论了尺寸、zeta电位、温度和pH作为影响人参纳米颗粒合成质量的关键参数。
