Zhuang Xiaodong, Ma Ting, Liu Risheng, Fang Xingyue, Huang Liangjiu
Department of Clinical Pharmacy, Hainan Cancer Hospital, Haikou, China.
Department of Pharmacy and Engineering Research Center of Tropical Medicine Innovation and Transformation, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China.
Front Chem. 2025 Mar 17;13:1552298. doi: 10.3389/fchem.2025.1552298. eCollection 2025.
The extract of medicinal plants is increasingly popular around the whole world due to its attractive therapeutic effects. However, the bioavailability of the extract of bioactive compounds was barely satisfactory due to its easily deactivated and untargeted properties. The use of nanotechnology to develop novel carrier delivery techniques for bioactive extracts has been proven to have significant potential and provides an amazing improvement in the therapeutic effect. Calcium carbonate nanoparticles (CaCO NPs), as representative biodegradable materials, are well recognized as environmentally responsive delivery vehicles for disease treatment. In this study, extracts of the root of ginseng, the fruit of Miq., and the stem of Champ. were developed as a CaCO nanoparticle loading drug. All of the three composite nanoparticles exhibited spherical shapes with a narrow size distribution. Notably, the ginseng extract-loaded CaCO NPs hold a relatively higher entrapment efficiency of up to 55.2% ± 6.7% and excellent release performance under acidic conditions (pH = 5.5). Moreover, intravenous injection of ginseng CaCO NPs resulted in significantly enhanced therapeutic effects in the treatment of glioma. The results demonstrate that CaCO-based composite nanoparticles are ideal for the delivery of plant extracts, and the systems are expected to be effective against various types of diseases in the future.
药用植物提取物因其诱人的治疗效果在全球越来越受欢迎。然而，由于生物活性化合物提取物易失活且无靶向性，其生物利用度难以令人满意。利用纳米技术开发生物活性提取物的新型载体递送技术已被证明具有巨大潜力，并能显著提高治疗效果。碳酸钙纳米颗粒（CaCO NPs）作为典型的可生物降解材料，被公认为是用于疾病治疗的环境响应性递送载体。在本研究中，人参根、五味子果实和南蛇藤茎的提取物被开发为负载CaCO纳米颗粒的药物。所有这三种复合纳米颗粒均呈球形，粒径分布狭窄。值得注意的是，负载人参提取物的CaCO NPs具有相对较高的包封率，高达55.2%±6.7%，且在酸性条件（pH = 5.5）下具有优异的释放性能。此外，静脉注射人参CaCO NPs在治疗胶质瘤方面产生了显著增强的治疗效果。结果表明，基于CaCO的复合纳米颗粒是植物提取物递送的理想载体，并且该系统有望在未来有效对抗各种类型的疾病。
