Zhang Jingyu, Zhao Bingkun, Wei Wuhan, Wang Dan, Wang Haoyu, Zhang Aijun, Tao Changbo, Li Xueyang, Li Qiang, Jin Peisheng
Department of Plastic Surgery, Affiliated Hospital of Xuzhou Medical University; Graduate School, Xuzhou Medical University.
Department of Plastic Surgery, Affiliated Hospital of Xuzhou Medical University.
J Vis Exp. 2023 Mar 3(193). doi: 10.3791/65045.
With the development of society and the economy, the incidence of diabetic foot ulcers continues to increase. Currently, conventional debridement with dressing changes, hyperbaric oxygen, and vacuum sealing drainage are the main conservative treatments in clinical practice, and large wounds often require skin grafts or skin flap grafts. However, the treatment effects are not ideal, and many complications exist. Due to its complex pathogenesis, long treatment time, significant associated difficulties, and high disability rate, diabetic foot ulcers cause a heavy burden to patients, society, and medical care. According to our previous study, the pharmacological effects of human umbilical cord blood stem cells include nonspecific immune regulation; increased secretion of growth factors, vasoactive factors, and anti-inflammatory factors; enhanced anti-infectious ability of the human body; elimination of inflammation; and promotion of angiogenesis and ulcer healing. These effects suggest stem cells may be useful as an autologous or allogeneic treatment for refractory wounds. Therefore, we are conducting a clinical trial to treat refractory diabetic wounds with human umbilical cord stem cells in our clinic for diabetic foot ulcer patients who meet the inclusion criteria.
随着社会和经济的发展，糖尿病足溃疡的发病率持续上升。目前，临床实践中主要的保守治疗方法包括常规清创换药、高压氧治疗和负压封闭引流，对于较大创面常需进行植皮或皮瓣移植。然而，治疗效果并不理想，且存在诸多并发症。由于其发病机制复杂、治疗时间长、相关困难显著以及致残率高，糖尿病足溃疡给患者、社会和医疗保健带来了沉重负担。根据我们之前的研究，人脐带血干细胞的药理作用包括非特异性免疫调节；增加生长因子、血管活性因子和抗炎因子的分泌；增强人体抗感染能力；消除炎症；促进血管生成和溃疡愈合。这些作用表明干细胞可能作为难治性伤口的自体或异体治疗手段。因此，我们正在本诊所针对符合纳入标准的糖尿病足溃疡患者开展一项用人脐带干细胞治疗难治性糖尿病伤口的临床试验。
