Hefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, University of Science and Technology of China, Hefei, Anhui 230026, China.
Institute of Energy, Hefei Comprehensive National Science Center, Hefei, Anhui 230031, P. R. China.
J Org Chem. 2023 Apr 7;88(7):4325-4333. doi: 10.1021/acs.joc.2c02923. Epub 2023 Mar 20.
Photocatalytic oxidation is a popular transformation way for organic synthesis and is widely applied in academia and industry. Herein, we report a blue light-induced alkylation-oxidation tandem reaction for the synthesis of diverse ketones by combining alkyl radical addition and oxidation of alkenyl borates. This reaction shows excellent functional group compatibility in acceptable yields, and diversity of radical precursors is applicable.
光催化氧化是一种常用的有机合成转化方法，在学术界和工业界得到了广泛的应用。在此，我们报道了一种蓝光诱导的烷基化-氧化串联反应，通过结合烷基自由基加成和烯基硼酸的氧化，用于合成各种酮。该反应在可接受的产率下显示出优异的官能团兼容性，并且自由基前体的多样性是适用的。
