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一种新型的、极端低成本的聚（赤藓红）修饰铅笔石墨电极，用于测定肾上腺素。

A novel, extreme low-cost poly (Erythrosine) modified pencil graphite electrode for determination of Adrenaline.

机构信息

Department of P.G. Studies and Research in Analytical Chemistry, Alva's College, Moodubidire, Dakshina Kannada, Karnataka, 574227, India.

Department of P.G. Studies and Research in Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shivmoga, Karnataka, 577451, India.

出版信息

Sci Rep. 2023 Mar 20;13(1):4523. doi: 10.1038/s41598-023-31068-y.

DOI:10.1038/s41598-023-31068-y
PMID:36941302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10027675/
Abstract

A simple, novel, and less cost yellow (Erythrosine) modified pencil graphite electrode (Po-ERY/MGPE) was successfully fabricated via electropolymerization method using cyclic voltammetric techniques. The fabricated Po-ERY/MGPE opted as a sensor for the detection of Adrenaline (ADR) in 0.2 M PBS (7.4 pH). This reported senor displayed excellent electrocatalytic activity, increased sensitivity, high stability, superior electron transfer kinetics in the oxidation of ADR once relative to BGPE. The significance of pH, scan rate, and impact of concentration was assessed at the sensor. As per the pH and scan rate study, redox routes carry the same number of electrons and protons, and electro-oxidation of ADR was adsorption controlled respectively. The LOD of ADR was found to be 0.499 µM. The DPV data indicate that there is a significant peak divergence among ADR and uric acid (UA) which could make it easier to determine them alone and simultaneously on the sensor. The described method has been employed for the determination of ADR in injection sample. Good recovery values indicate the efficacy and applicability of the sensor in detecting ADR.

摘要

通过循环伏安技术，成功地用电聚合方法制备了一种简单、新颖且成本较低的黄色（赤藓红）修饰铅笔芯石墨电极（Po-ERY/MGPE）。所制备的 Po-ERY/MGPE 作为传感器，用于在 0.2 M PBS（pH7.4）中检测肾上腺素（ADR）。与 BGPE 相比，该报道的传感器显示出优异的电催化活性、更高的灵敏度、更高的稳定性和优越的电子转移动力学，用于 ADR 的氧化。评估了传感器中 pH、扫描速率和浓度的影响。根据 pH 和扫描速率的研究，氧化还原途径携带相同数量的电子和质子，ADR 的电氧化分别受吸附控制。ADR 的检出限为 0.499 µM。DPV 数据表明，ADR 和尿酸（UA）之间存在明显的峰发散，这使得在传感器上单独和同时测定它们变得更加容易。该方法已用于注射液中 ADR 的测定。良好的回收率值表明传感器在检测 ADR 方面的有效性和适用性。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a4b/10027675/1af113fc78d9/41598_2023_31068_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a4b/10027675/96e281b38e39/41598_2023_31068_Fig8_HTML.jpg
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