二甲基亚砜增强大鼠嘌呤霉素氨基核苷肾病。
DMSO potentiates aminonucleoside of puromycin nephrosis in rats.
作者信息
Spear G S, Nguyen D, Conklin S, Wikle J S, Fan J, Lan Y H, Allen J, Reineck S
机构信息
Department of Pathology, California College of Medicine, University of California at Irvine 92717.
出版信息
J Pathol. 1987 Oct;153(2):183-7. doi: 10.1002/path.1711530212.
Dimethyl sulphoxide (DMSO), 3 g/kg body weight, administered daily by the intraperitoneal route, potentiated the proteinuria and formation of tubular casts in aminonucleoside of puromycin (PA) induced nephrosis in Sprague-Dawley rats. The effect was evident at 4 as well as 8-9 days following PA administration. In the absence of PA, DMSO did not induce proteinuria or cast formation. The mechanism by which DMSO enhanced proteinuria and cast formation is not known.
二甲基亚砜（DMSO），按3克/千克体重，通过腹腔注射途径每日给药，可增强嘌呤霉素氨基核苷（PA）诱导的斯普拉格-道利大鼠肾病中的蛋白尿和肾小管管型形成。在给予PA后4天以及8 - 9天，这种作用很明显。在没有PA的情况下，DMSO不会诱导蛋白尿或管型形成。DMSO增强蛋白尿和管型形成的机制尚不清楚。
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