DMSO potentiates aminonucleoside of puromycin nephrosis in rats.
作者信息
Spear G S, Nguyen D, Conklin S, Wikle J S, Fan J, Lan Y H, Allen J, Reineck S
机构信息
Department of Pathology, California College of Medicine, University of California at Irvine 92717.
出版信息
J Pathol. 1987 Oct;153(2):183-7. doi: 10.1002/path.1711530212.
PMID:3694323
Abstract
Dimethyl sulphoxide (DMSO), 3 g/kg body weight, administered daily by the intraperitoneal route, potentiated the proteinuria and formation of tubular casts in aminonucleoside of puromycin (PA) induced nephrosis in Sprague-Dawley rats. The effect was evident at 4 as well as 8-9 days following PA administration. In the absence of PA, DMSO did not induce proteinuria or cast formation. The mechanism by which DMSO enhanced proteinuria and cast formation is not known.
摘要
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