Obstetrics and Gynaecology Department, Complexo Hospitalario Universitario de Ourense, C/ Ramón Puga 54, 32005, Ourense, Spain.
Food and Health Omics, Analytical and Food Chemistry Department, Campus da Auga, Faculty of Sciences, University of Vigo, 32004, Ourense, Spain.
Environ Sci Pollut Res Int. 2023 May;30(22):62566-62578. doi: 10.1007/s11356-023-26560-x. Epub 2023 Mar 21.
Adequate gestational progression depends to a great extent on placental development, which can modify maternal and neonatal outcomes. Any environmental toxicant, including metals, with the capacity to affect the placenta can alter the development of the pregnancy and its outcome. The objective of this study was to correlate the placenta levels of 14 essential and non-essential elements with neonatal weight. We examined relationships between placental concentrations of arsenic, cadmium, cobalt, copper, mercury, lithium, manganese, molybdenum, nickel, lead, rubidium, selenium, strontium, and zinc from 79 low obstetric risk pregnant women in Ourense (Northwestern Spain, 42°20'12.1″N 7°51.844'O) with neonatal weight. We tested associations between placental metal concentrations and neonatal weight by conducting multivariable linear regressions using generalized linear models (GLM) and generalized additive models (GAM). While placental Co (p = 0.03) and Sr (p = 0.048) concentrations were associated with higher neonatal weight, concentrations of Li (p = 0.027), Mo (p = 0.049), and Se (p = 0.02) in the placenta were associated with lower newborn weight. Our findings suggest that the concentration of some metals in the placenta may affect fetal growth.
充足的妊娠进展在很大程度上取决于胎盘的发育，而胎盘的发育会影响母婴的结局。任何具有影响胎盘能力的环境毒物，包括金属，都可能改变妊娠的发展及其结局。本研究的目的是将胎盘的 14 种必需和非必需元素水平与新生儿体重相关联。我们检查了西班牙西北部奥伦塞（42°20'12.1″N 7°51.844'O）的 79 名低产科风险孕妇的胎盘砷、镉、钴、铜、汞、锂、锰、钼、镍、铅、铷、硒、锶和锌浓度与新生儿体重之间的关系。我们通过使用广义线性模型（GLM）和广义加性模型（GAM）进行多元线性回归来测试胎盘金属浓度与新生儿体重之间的关联。虽然胎盘 Co（p=0.03）和 Sr（p=0.048）浓度与较高的新生儿体重相关，但是胎盘内 Li（p=0.027）、Mo（p=0.049）和 Se（p=0.02）的浓度与新生儿体重较低相关。我们的研究结果表明，胎盘内某些金属的浓度可能会影响胎儿的生长。
