Beijing National Laboratory for Molecular Sciences CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems, CAS Research/Education Center of Excellence in Molecular Sciences Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
School of Chemistry, University of Chinese Academy of Sciences, Beijing, 100049, China.
Chemistry. 2023 May 26;29(30):e202300539. doi: 10.1002/chem.202300539. Epub 2023 Apr 20.
Molecular probes which can be modulated, functionalized and used to visualize the processes are highly desirable for understanding and manipulating biological systems. Geometric cis and trans isomers of tetraphenylethene (TPE) emerge as attractive candidates to fulfill these tasks thanks to the unique aggregation-induced emission properties, tailorable structures, and responsiveness to external stimuli. This minireview focuses on cis and trans isomers of TPE derivatives that are functionalized with molecular recognition units for fluorescence detection, bioimaging and cancer therapy. The effects of molecular geometry on fluorescence property, target binding ability and biological activity are summarized. The feasibility to in vitro and in vivo switch molecular configuration and thus bio-activity is discussed. Finally, the future development and challenges are discussed in view of TPE-based stereoisomers for targeted sensing and imaging-guided modulation of biological processes.
对于理解和操纵生物系统，人们非常希望使用能够被调控、功能化并用于可视化的分子探针。由于具有独特的聚集诱导发射特性、可调节的结构以及对外界刺激的响应性，四苯乙烯（TPE）的几何顺反异构体成为满足这些要求的有吸引力的候选物。本文综述了功能化的 TPE 衍生物的顺反异构体，这些顺反异构体带有分子识别单元，可用于荧光检测、生物成像和癌症治疗。总结了分子几何形状对荧光性质、靶标结合能力和生物活性的影响。讨论了在体外和体内切换分子构型从而改变生物活性的可行性。最后，根据基于 TPE 的立体异构体，针对靶向传感和成像引导的生物过程调节，讨论了未来的发展和挑战。
