Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Center for Low-Temperature Plasma Sciences, Nagoya University, Nagoya, Japan.
Free Radic Res. 2023 Feb;57(2):69-80. doi: 10.1080/10715762.2023.2193308. Epub 2023 Mar 28.
Cancer therapy consists of multidisciplinary treatment combining surgery, chemotherapy, radiotherapy, and immunotherapy. Despite the elucidation of cancer mechanisms by comprehensive genomic and epigenomic analyses and the development of molecular therapy, drug resistance and severe side effects have presented challenges to the long-awaited development of new therapies. With the rapid technological advances in the last decade, there are now reports concerning potential applications of non-equilibrium atmospheric pressure plasma (NEAPP) in cancer therapy. Two approaches have been tried: direct irradiation with NEAPP (direct plasma) and the administration of a liquid (e.g. culture medium, saline, Ringer's lactate) activated by NEAPP (plasma-activated solutions: PAS). Direct plasma is a unique treatment method in which various active species, charged ions, and photons are delivered to the affected area, but the direct plasma approach has physical limitations related to the device used, such as a limited depth of reach and limited irradiation area. PAS is a liquid that contains reactive oxygen species generated by PAS, and it has been confirmed to have antitumor activity that functions in the same manner as direct plasma. This review introduces recent studies of PAS and informs researchers about the potential of PAS for cancer therapy.
癌症治疗包括多学科治疗，结合手术、化疗、放疗和免疫治疗。尽管通过全面的基因组和表观基因组分析阐明了癌症机制，并开发了分子治疗，但耐药性和严重的副作用给新疗法的期待已久的发展带来了挑战。随着过去十年技术的快速进步，现在有关于非平衡大气压等离子体（NEAPP）在癌症治疗中潜在应用的报道。已经尝试了两种方法：用 NEAPP 直接照射（直接等离子体）和用 NEAPP 激活的液体（例如培养基、盐水、林格氏乳酸盐）给药（等离子体激活溶液：PAS）。直接等离子体是一种独特的治疗方法，其中将各种活性物质、带电离子和光子输送到受影响的区域，但直接等离子体方法受到与所使用的设备相关的物理限制，例如有限的到达深度和有限的照射区域。PAS 是一种液体，其中包含 PAS 产生的活性氧物质，已证实它具有与直接等离子体相同作用方式的抗肿瘤活性。本综述介绍了 PAS 的最新研究，并告知研究人员 PAS 用于癌症治疗的潜力。
