Watanabe H
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
J Pharmacobiodyn. 1987 Jul;10(7):317-20. doi: 10.1248/bpb1978.10.317.
The purpose of this study was to investigate age-related changes in in vivo dopamine (DA) synthesis in the brain of Wistar rats of ST and LWH substrains. There were no significant differences in the regional DA levels in aged versus mature rats of both substrains. In the LWH substrain, the in vivo DA synthesis as reflected in 3,4-dihydroxyphenylalanine accumulation in the striatum and nucleus accumbens was significantly lower in the aged rats. In the ST substrain, however, no age-related changes in the regional in vivo DA synthesis were observed for the mature rats. These results suggested that the striatum and nucleus accumbens of the LWH rats may be more vulnerable to aging than those of ST substrain.
本研究的目的是调查ST和LWH亚系Wistar大鼠大脑中与年龄相关的体内多巴胺（DA）合成变化。两个亚系的老年大鼠与成熟大鼠的区域DA水平均无显著差异。在LWH亚系中，老年大鼠纹状体和伏隔核中3,4-二羟基苯丙氨酸积累所反映的体内DA合成显著降低。然而，在ST亚系中，未观察到成熟大鼠区域体内DA合成的年龄相关变化。这些结果表明，LWH大鼠的纹状体和伏隔核可能比ST亚系更容易受到衰老的影响。
