Department of Cell Biology and Genetics, Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, Key Laboratory of Hengyang City on Biological Toxicology and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and Health Hazards, University of South China, Hengyang, Hunan421001, People's Republic of China.
Department of Obstetrics and Gynecology, the Second Affiliated Hospital, University of South China, 30# Jiefang Road, Hengyang, Hunan421001, People's Republic of China.
Br J Nutr. 2023 Nov 28;130(10):1657-1664. doi: 10.1017/S0007114523000764. Epub 2023 Mar 22.
In recent years, obesity is a growing pandemic in the world and has likely contributed to increasing the incidence of obesity-related diseases. Fat mass and obesity-associated gene () is the first gene discovered which has a close connection with fat. Recent studies suggested that gene has played an important role in the molecular mechanisms of many diseases. Obesity is considered to be a hereditary disease and can evoke many kinds of diseases, including polycystic ovary syndrome (PCOS), type 2 diabetes mellitus (T2DM), cancer, etc., whose exact possible molecular mechanisms responsible for the effect of on obesity and obesity-related diseases remain largely unknown. In this review, we comprehensively discuss the correlation between gene and obesity, cancer, PCOS, T2DM, as well as the molecular mechanism involved in these diseases.
近年来，肥胖是全球日益严重的流行疾病，可能导致肥胖相关疾病的发病率上升。脂肪量和肥胖相关基因（）是第一个被发现与脂肪密切相关的基因。最近的研究表明，基因在许多疾病的分子机制中发挥了重要作用。肥胖被认为是一种遗传性疾病，可以引发多种疾病，包括多囊卵巢综合征（PCOS）、2 型糖尿病（T2DM）、癌症等，但其对肥胖和肥胖相关疾病的确切可能的分子机制仍知之甚少。在这篇综述中，我们全面讨论了基因与肥胖、癌症、PCOS、T2DM 之间的相关性，以及这些疾病涉及的分子机制。
