Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Yuanmingyuan west road 2, Beijing, 100193, China.
Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Yuanmingyuan west road 2, Beijing, 100193, China; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Food Chem Toxicol. 2023 May;175:113737. doi: 10.1016/j.fct.2023.113737. Epub 2023 Mar 20.
Obesity caused by endocrine disruptors (EDCs) has become a hot topic threatening human health. Recently, Nanoselenium Siraitia grosvenorii (NSG) has been shown to have potential health-modulating uses. Based on the results of 16S rRNA sequencing and metabolomics analysis, NSG has the unique function of improving gut microbiota and inhibiting obesity. Specifically, NSG can enhance gut microbiota diversity and change their composition. A significant positive correlation exists between the liver change in lysine and the high-importance dominant species ([Ruminococcus]_gnavus, Alistipes_finegoldii, etc.). NSG metabolites analysis showed that the lysine level increased by 44.45% and showed a significantly negatively correlated with (TG, TC, Leptin, etc.). Significantly, NSG reduces the degradation of lysine metabolism in the liver and inhibits fatty acid β-oxidation. In addition, NSG decreased Acetyl-CoA levels by 24% and regulated the downregulation of TCA genes (CS, Ogdh, Fh1, and Mdh2) and the upregulation of ketone body production genes (BDH1). NSG may have a positive effect on obesity by reducing the participation of Acetyl-CoA in the TCA cycle pathway and enhancing the ketogenic conversion of Acetyl-CoA. In conclusion, the results of this study may provide a new dietary intervention strategy for preventing endocrine disruptor-induced obesity.
内分泌干扰物 (EDCs) 引起的肥胖已成为威胁人类健康的热门话题。最近，研究表明，纳米硒罗汉果（NSG）具有潜在的健康调节作用。基于 16S rRNA 测序和代谢组学分析的结果，NSG 具有改善肠道微生物群和抑制肥胖的独特功能。具体来说，NSG 可以增强肠道微生物群的多样性并改变其组成。赖氨酸的肝脏变化与高重要优势种 ([Ruminococcus]_gnavus、Alistipes_finegoldii 等) 之间存在显著正相关。NSG 代谢物分析表明，赖氨酸水平增加了 44.45%，并与 (TG、TC、Leptin 等) 呈显著负相关。值得注意的是，NSG 减少了肝脏中赖氨酸代谢的降解，并抑制了脂肪酸 β-氧化。此外，NSG 使乙酰辅酶 A 水平降低了 24%，并调节 TCA 基因（CS、Ogdh、Fh1 和 Mdh2）的下调和酮体生成基因（BDH1）的上调。NSG 通过减少乙酰辅酶 A 参与 TCA 循环途径并增强乙酰辅酶 A 的生酮转化，可能对肥胖产生积极影响。总之，本研究的结果可能为预防内分泌干扰物引起的肥胖提供一种新的饮食干预策略。
