Song Jingru, Wei Yulu, Lu Fenglai, Li Dianpeng, Liu Hongwei, Yan Xiaojie, Jiang Xiaohua
Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin, China.
Engineering Research Center of Innovative Traditional Chinese, Zhuang and Yao Materia Medica, Ministry of Education, Guangxi University of Chinese Medicine, Nanning, China.
Plant Foods Hum Nutr. 2024 Dec 30;80(1):26. doi: 10.1007/s11130-024-01260-0.
Monk fruit is the mature fruit of Siraitia grosvenorii (Swingle) C. Jeffrey (SG), which contains mogrosides and various nutrients with diverse benefits as a traditional edible herb. The immunomodulatory effects of the ingredients of monk fruit in daily diets are poorly understood. Monk fruit juice concentrate is a commercial product of monk fruit and in this study, the immune-enhancing activity, immunosuppressive prevention, and gut microbiota modulatory effects of the long-term consumption of its diluent (called SG juice) in daily drinking were investigated in both healthy and cyclophosphamide (CTX)-treated mice. The results indicated that SG juice consumption was beneficial to weight management and improved immunity in mice by enhancing various immune factors. 16S rRNA analysis found that SG juice impacted the diversity and gut microbiota composition with the enrichment of immune-related flora, including Alloprevotella, Bifidobacterium_pseudolongum, Lactobacillus, and Bacteroides_sartorii. Additionally, the daily intake of SG juice exerted preventive effects on immunosuppressive mice with the recovery of reduced body weight and immunoglobulin levels, and restoration of gut microbiota imbalance. These data provide scientific insights into the immunomodulatory effects of monk fruit and foresee its application in functional foods.
罗汉果是罗汉果（Siraitia grosvenorii (Swingle) C. Jeffrey，简称SG）的成熟果实，作为一种传统的可食用草药，它含有罗汉果甜苷和各种具有多种益处的营养成分。人们对日常饮食中罗汉果成分的免疫调节作用了解甚少。罗汉果浓缩汁是罗汉果的一种商业产品，在本研究中，我们在健康小鼠和环磷酰胺（CTX）处理的小鼠中，研究了日常饮用其稀释液（称为SG汁）长期摄入后的免疫增强活性、免疫抑制预防作用和肠道微生物群调节作用。结果表明，饮用SG汁有利于小鼠体重管理，并通过增强各种免疫因子提高小鼠免疫力。16S rRNA分析发现，SG汁影响肠道微生物群的多样性和组成，使包括Alloprevotella、假长双歧杆菌、乳酸杆菌和萨托氏拟杆菌在内的免疫相关菌群富集。此外，每日摄入SG汁对免疫抑制小鼠具有预防作用，可使体重减轻和免疫球蛋白水平恢复正常，并恢复肠道微生物群失衡状态。这些数据为罗汉果的免疫调节作用提供了科学见解，并预见到其在功能性食品中的应用。
