Xu Guoqiang, Zhang Xiaomei, Xiao Wenhan, Shi Jinsong, Xu Zhenghong
The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China.
National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi, China.
Crit Rev Biotechnol. 2024 May;44(3):448-461. doi: 10.1080/07388551.2023.2170863. Epub 2023 Mar 21.
L-serine and its derivative L-cysteine have broad industrial applications, and their direct fermentative production from renewable biomass is gaining increasing attention. is an extensively studied and well-established industrial microorganism, which is a predominant microbial host for producing amino acids. In this review, updated information on the genetics and molecular mechanisms underlying L-serine and L-cysteine production using is presented, including their synthesis and degradation pathways, and other intracellular processes related to their production, as well as the mechanisms underlying substrate import and product export are also analyzed. Furthermore, metabolic strategies for strain improvement are systematically discussed, and conclusions and future perspectives for bio-based L-serine and L-cysteine production using are presented. This review can provide a thorough understanding of L-serine and L-cysteine metabolic pathways to facilitate metabolic engineering modifications of and development of more efficient industrial fermentation processes for L-serine and L-cysteine production.
L-丝氨酸及其衍生物L-半胱氨酸具有广泛的工业应用，利用可再生生物质直接发酵生产它们正受到越来越多的关注。[具体微生物名称未给出]是一种经过广泛研究且成熟的工业微生物，是生产氨基酸的主要微生物宿主。在这篇综述中，介绍了关于利用[具体微生物名称未给出]生产L-丝氨酸和L-半胱氨酸的遗传学和分子机制的最新信息，包括它们的合成和降解途径、与它们生产相关的其他细胞内过程，同时也分析了底物导入和产物输出的机制。此外，系统地讨论了菌株改良的代谢策略，并给出了利用[具体微生物名称未给出]进行生物基L-丝氨酸和L-半胱氨酸生产的结论和未来展望。这篇综述可以提供对L-丝氨酸和L-半胱氨酸代谢途径的全面理解，以促进对[具体微生物名称未给出]的代谢工程改造以及开发更高效的L-丝氨酸和L-半胱氨酸工业发酵工艺。
