Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Department of Oncology, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Int J Nanomedicine. 2023 Mar 15;18:1299-1315. doi: 10.2147/IJN.S396863. eCollection 2023.
Chemotherapy still plays a dominant role in cancer treatment. However, the inability of conventional chemotherapeutic drugs to reach the hypoxic zone of solid tumors significantly weakens their efficacy. Bacteria-mediated drug delivery systems can be an effective targeting strategy for improving the therapeutic outcomes in cancer. Anaerobic bacteria have the unique ability to selectively transport drug loads to the hypoxic regions of tumors.
We designed a (Bif)-based biohybrid (Bif@PDA-PTX-NPs) to deliver polydopamine (PDA)-coated paclitaxel nanoparticles (PTX-NPs) to tumor tissues.
The self-driven Bif@PDA-PTX-NPs maintained the toxicity of PTX as well as the hypoxic homing tendency of Bif. Furthermore, Bif@PDA-PTX-NPs significantly inhibited the growth of A549 xenografts in nude mice, and prolonged the survival of the tumor-bearing mice compared to the other PTX formulations without any systemic or localized toxicity.
The Bif@PDA-PTX-NPs biohybrids provide a new therapeutic strategy for targeted chemotherapy to solid tumors.
化疗在癌症治疗中仍占主导地位。然而，传统化疗药物无法到达实体瘤的缺氧区，这大大降低了它们的疗效。细菌介导的药物传递系统可以成为提高癌症治疗效果的有效靶向策略。厌氧菌具有将药物有效负载选择性输送到肿瘤缺氧区的独特能力。
我们设计了一种基于双歧杆菌的生物杂交体（Bif@PDA-PTX-NPs），将载有聚多巴胺（PDA）的紫杉醇纳米颗粒（PTX-NPs）递送到肿瘤组织中。
自驱动的 Bif@PDA-PTX-NPs 保持了 PTX 的毒性以及双歧杆菌的缺氧归巢倾向。此外，与其他没有全身或局部毒性的 PTX 制剂相比，Bif@PDA-PTX-NPs 显著抑制了裸鼠 A549 异种移植瘤的生长，并延长了荷瘤小鼠的存活时间。
Bif@PDA-PTX-NPs 生物杂交体为针对实体瘤的靶向化疗提供了一种新的治疗策略。
