State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
College of Science, Huazhong Agricultural University, Wuhan 430070, PR China.
ACS Nano. 2021 Dec 28;15(12):19321-19333. doi: 10.1021/acsnano.1c05605. Epub 2021 Dec 1.
Chemodynamic therapy (CDT) destroys cancer cells by converting HO or O into reactive oxygen species (ROS), but its therapeutic efficacy is restricted by the antioxidant capacity of tumor. Previous solutions focused on strengthening the nanodrugs with the ability to increase ROS production or weaken the antioxidant capacity of cancer cells. Conversely, we here develop a mild nanodrug with negligible side effects. Specifically, the Au@Pt nanozyme decorated on a bacterial surface (Bac-Au@Pt) is reported to achieve precise CDT. Due to the tumor targeting ability of bacteria and catalytic property of Au@Pt nanozyme under acidic conditions, this nanosystem can release ROS to tumor cells effectively. In addition, the interferon gamma released by T cells specifically decreases the intracellular reductants in tumor cells, while having no obvious effect on normal cells. Therefore, a low dose of Bac-Au@Pt achieves a satisfactory therapeutic efficacy to tumor cells and is nontoxic to normal cells even at their acidic components. This nanosystem enables CDT and immunotherapy to mutually benefit and improve by each other, providing a promising strategy to achieve high anticancer efficacy even with a low dose usage.
化学动力学疗法 (CDT) 通过将 HO 或 O 转化为活性氧 (ROS) 来杀死癌细胞，但它的治疗效果受到肿瘤抗氧化能力的限制。以前的解决方案主要集中在增强纳米药物增加 ROS 产生的能力或削弱癌细胞的抗氧化能力。相反，我们在这里开发了一种副作用极小的温和纳米药物。具体来说，报道称细菌表面修饰的 Au@Pt 纳米酶（Bac-Au@Pt）可实现精确的 CDT。由于细菌的肿瘤靶向能力和 Au@Pt 纳米酶在酸性条件下的催化特性，该纳米系统可以有效地向肿瘤细胞释放 ROS。此外，T 细胞释放的干扰素 γ 特异性降低肿瘤细胞内的还原剂，而对正常细胞几乎没有明显影响。因此，低剂量的 Bac-Au@Pt 可实现对肿瘤细胞的令人满意的治疗效果，即使在酸性成分下，对正常细胞也没有毒性。该纳米系统使 CDT 和免疫疗法相互受益并相互改善，为实现高抗癌效果提供了一种有前途的策略，即使使用低剂量。
