Tomše Patricija, Balkovec Valerija
Department of Dermatovenerology, Novo mesto General Hospital, Novo mesto, Slovenia.
Acta Dermatovenerol Alp Pannonica Adriat. 2023 Mar;32(1):25-28.
Primary biliary cholangitis is a chronic progressive cholestatic granulomatous and destructive inflammatory lesion of small intralobular and septal bile ducts that primarily affects women. The exact etiology of this disease has not yet been elucidated; however, it is believed to be the result of a combination of environmental triggers in genetically predisposed individuals. It can manifest itself simultaneously with, before, or after the onset of psoriasis and other skin autoimmune diseases. Standard treatment is ursodeoxycholic acid. A 65-year-old patient presenting with elevated hepatic laboratory findings that had persisted for several years and normal abdominal ultrasound was additionally diagnosed with primary biliary cholangitis after 2 years on a biological drug for psoriasis. She did not have other symptoms except elevated liver tests. The skin showed a strong response to biological therapy and treatment with ursodeoxycholic acid prompted lowering of liver enzymes. The skin was clear all throughout the treatment. This article emphasizes the importance of additional diagnostic workups in patients with psoriasis and elevated hepatic laboratory findings.
原发性胆汁性胆管炎是一种慢性进行性胆汁淤积性肉芽肿性和破坏性炎症性病变，主要累及小叶内和间隔小胆管，主要影响女性。该病的确切病因尚未阐明；然而，据信它是遗传易感性个体中环境触发因素综合作用的结果。它可与银屑病和其他皮肤自身免疫性疾病同时、在其发作之前或之后出现。标准治疗是熊去氧胆酸。一名65岁患者，肝脏实验室检查结果升高持续数年，腹部超声正常，在使用生物药物治疗银屑病2年后，额外诊断为原发性胆汁性胆管炎。除肝功能检查升高外，她没有其他症状。皮肤对生物治疗反应强烈，使用熊去氧胆酸治疗促使肝酶降低。在整个治疗过程中皮肤保持清洁。本文强调了对银屑病患者和肝脏实验室检查结果升高患者进行额外诊断检查的重要性。
